Trial reportEuropean journal of clinical nutrition2011
Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans.
Trial report in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03375125 (Safety and Efficacy of L. Reuteri ATCC PTA 5289 & L. Reuteri DSM 17938 in Pregnant Women to Improve Oral Health and Reduce the Risk for Prematurity or Intrauterine Growth Retardation), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of L. Reuteri ATCC PTA 5289 & L. Reuteri DSM 17938 in Pregnant Women to Improve Oral Health and Reduce the Risk for Prematurity or Intrauterine Growth Retardation (IUGR)
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Pooled it
- Are dairy products containing probiotics beneficial for oral health? A systematic review and meta-analysis.Clinical oral investigations · 2018Pooled it
- Pooled it
- Daily Probiotic Ayran Intake Reduces Gingival Inflammation: An Experimental Gingivitis Study.Oral health & preventive dentistry · 2024Trial
- Trial
- Trial
- Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis.Clinical oral investigations · 2023Trial
- Psychophysiological Effects ofNutrients · 2021Trial
- The Effect ofPolish journal of microbiology · 2020Trial
- Noninferiority Randomized Controlled Clinical Trial Assessing the Antiplaque Efficacy of Fatty Acids-Based Mouthrinse.Clinical and experimental dental research · 2025Article
- The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties.Microorganisms · 2024Review
- Knowledge and Attitude towards Probiotics among Dental Students and Teachers: A Cross-Sectional Survey.Dentistry journal · 2023Article
- A comprehensive review of the application of probiotics and postbiotics in oral health.Frontiers in cellular and infection microbiology · 2023Review
- Cranberry Arabino-Xyloglucan and Pectic Oligosaccharides InduceMicroorganisms · 2022Article
- Probiotics During the Therapeutic Management of Periodontitis.Advances in experimental medicine and biology · 2022Review
- Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis.Nutrients · 2021Article
- A Review of the Role of Probiotic Supplementation in Dental Caries.Probiotics and antimicrobial proteins · 2020Review
- Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis.PloS one · 2019Article
- Ecological Therapeutic Opportunities for Oral Diseases.Microbiology spectrum · 2017Review
- Exploring the Association between Alzheimer's Disease, Oral Health, Microbial Endocrinology and Nutrition.Frontiers in aging neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the effects of a probiotic milk drink consumed over a period of 28 days, regarding the expression of clinical inflammatory parameters of the oral gingiva during various phases of plaque-induced gingivitis.
methodsTwenty-eight adults with healthy gingiva took part in a prospective and clinical-controlled study. The test group was advised to consume a probiotic milk drink (Yacult) daily during a period of 4 weeks; the control group did not receive any probiotic food or drink. After 2 weeks of consumption of the probiotic drink, participants were advised not to brush their teeth for 14 days. Subsequently, at baseline as well as on days 1, 3, 5, 7 and 14, the following clinical parameters were assessed: plaque index (PI), gingival index (GI), gingival crevicular fluid (GCF) volume and bleeding on probing (BOP).
resultsAt baseline, the PI was significantly higher in the test group compared with controls (0.44±0.50 vs 0.09±0.24 PI; P=0.0001). The termination of oral hygiene increased clinical inflammatory parameters in both groups. At day 14, the parameters PI, GI, GCF volume and BOP were significantly higher compared with baseline values (P=0.0001). At day 14, BOP levels (18.75±12.32 vs 36.88±12.54%) and GCF volume (18.78±16.7 vs 35.72±16.1 Periotron units) were significantly lower in the test group compared with the control group (P=0.005).
conclusionThe results of our study indicate that a daily consumption of a probiotic milk drink reduces the effects of plaque-induced gingival inflammation associated with a higher plaque score due to the high-carbohydrate content of the probiotic milk beverage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.