Evidence map›Paper›PMID 21448208›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2011

Effects of delayed cord clamping in very-low-birth-weight infants.

W Oh, A A Fanaroff, W A Carlo, E F Donovan, S A McDonald, W K Poole, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02478684 (The Effects of Delayed Cord Clamping on Postnatal Circulatory Status in Preterm Neonates), which is not on this map. Cited by 32 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 9 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02478684 nacompletednot on this mapstarted 2015, after this paper: background citation

The Effects of Delayed Cord Clamping on Postnatal Circulatory Status in Preterm Neonates

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2015 to 2019Enrolled105ConditionsPremature Birth of Newborn, Infant, Very Low Birth Weight, Delayed Separation of Umbilical Cord, Placental TransfusionArms30 Seconds of placental blood transfusion, 60 Seconds of placental blood transfusion
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 9 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Antenatal and perinatal factors influencing neonatal blood pressure: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. [Influence of delayed cord clamping on preterm infants with a gestational age of <32 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016
    Trial
  13. Timing of umbilical cord clamping among infants born at 22 through 27 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016
    Trial
  14. Trial
  15. The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2013
    Trial
  16. Trial
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

W OhDepartment of Pediatrics, Women and Infants' Hospital, 101 Dudley Street, Providence, RI 02905, USA. woh@wihri.org
A A Fanaroff
W A Carlo
E F Donovan
S A McDonald
W K Poole
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
RTI International · USCase Western Reserve University · USUniversity of Alabama at Birmingham · USUniversity of Cincinnati · USWomen & Infants Hospital of Rhode Island · US

Funding

Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD034216 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 1996 to 2015
$6.4M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021364 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI WALSH, MICHELE · 1991 to 2015
$6.1M
NICHD NIH HHS U01 HD036790NICHD NIH HHS U01 HD36790NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD21364NICHD NIH HHS U10 HD27904NICHD NIH HHS U10 HD34216
6 · The paper itself

Abstract

objectiveDelayed cord clamping (DCC) may be beneficial in very-preterm and very-low-birth-weight infants. STUDY

designThis study was a randomized unmasked controlled trial. It was performed at three centers of the NICHD (National Institute of Child Health and Human Development) Neonatal Research Network. DCC in very-preterm and very-low-birth-weight infants will result in an increase in hematocrit levels at 4 h of age. Infants with a gestational age of 24 to 28 weeks were randomized to either early cord clamping (<10 s) or DCC (30 to 45 s). The primary outcome was venous hematocrit at 4 h of age. Secondary outcomes included delivery room management, selected neonatal morbidities and the need for blood transfusion during the infants' hospital stay.

resultA total of 33 infants were randomized: 17 to the immediate cord clamping group (cord clamped at 7.9±5.2 s, mean±s.d.) and 16 to the DCC (cord clamped at 35.2±10.1 s) group. Hematocrit was higher in the DCC group (45±8% vs 40±5%, P<0.05). The frequency of events during delivery room resuscitation was almost identical between the two groups. There was no difference in the hourly mean arterial blood pressure during the first 12 h of life; there was a trend in the difference in the incidence of selected neonatal morbidities, hematocrit at 2, 4 and 6 weeks, as well as the need for transfusion, but none of the differences was statistically significant.

conclusionA higher hematocrit is achieved by DCC in very-low-birth-weight infants, suggesting effective placental transfusion.

Indexed as

Infant, PrematureInfant, Very Low Birth WeightUmbilical CordConstrictionDelivery, ObstetricHematocritHumansInfant, Newborn

Identifiers

PMID21448208
PMCPMC3327157
OpenAlexW2130593863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.