Evidence map›Paper›PMID 21448207›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2011

Improved outcomes with a standardized feeding protocol for very low birth weight infants.

K R McCallie, H C Lee, O Mayer, R S Cohen, S R Hintz, W D Rhine

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03393832 (Oral Care), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03393832 active not recruitingnot on this mapstarted 2017, after this paper: background citation

Oral Care: An Important Adjunctive Therapy to Improve Feeding Tolerance in Infants With Gastroschisis

TypeobservationalSponsorBaylor College of MedicineRan2017 to 2026Enrolled27ConditionsGastroschisis
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Standardized feeding regimen for reducing necrotizing enterocolitis in preterm infants: an updated systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024
    Article
  9. Article
  10. Article
  11. Dilemmas in human milk fortification.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  12. Dilemmas in feeding infants with intestinal failure: a neonatologist's perspective.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC).Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

K R McCallieDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, 750 Welch Road, Palo Alto, CA 94304, USA. kmccallie@stanford.edu
H C Lee
O Mayer
R S Cohen
S R Hintz
W D Rhine

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
NCRR NIH HHS KL2 RR024130
6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate the impact of a standardized enteral feeding protocol for very low birth weight (VLBW) infants on nutritional, clinical and growth outcomes. STUDY

designRetrospective analysis of VLBW cohorts 9 months before and after initiation of a standardized feeding protocol consisting of 6-8 days of trophic feedings, followed by an increase of 20 ml/kg/day. The primary outcome was days to reach full enteral feeds defined as 160 ml/kg/day. Secondary outcomes included rates of necrotizing enterocolitis and culture-proven sepsis, days of parenteral nutrition and growth end points.

resultData were analyzed on 147 VLBW infants who received enteral feedings, 83 before ('Before') and 64 subsequent to ('After') feeding protocol initiation. Extremely low birth weight (ELBW) infants in the After group attained enteral volumes of 120 ml/kg/day (43.9 days Before vs 32.8 days After, P=0.02) and 160 ml/kg/day (48.5 days Before vs 35.8 days After, P=0.02) significantly faster and received significantly fewer days of parenteral nutrition (46.2 days Before vs 31.3 days After, P=0.01). Necrotizing enterocolitis decreased in the After group among VLBW (15/83, 18% Before vs 2/64, 3% After, P=0.005) and ELBW infants (11/31, 35% Before vs 2/26, 8% After, P=0.01). Late-onset sepsis decreased significantly in the After group (26/83, 31% Before vs 6/64, 9% After, P=0.001). Excluding those with weight <3rd percentile at birth, the proportion with weight <3rd percentile at discharge decreased significantly after protocol initiation (35% Before vs 17% After, P=0.03).

conclusionThese data suggest that implementation of a standardized feeding protocol for VLBW infants results in earlier successful enteral feeding without increased rates of major morbidities.

Indexed as

Enteral NutritionInfant, Very Low Birth WeightFood, FormulatedHumansInfant, Extremely Low Birth WeightInfant, NewbornInfant Nutritional Physiological PhenomenaParenteral Nutrition, Total

Identifiers

PMID21448207

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.