Evidence map›Paper›PMID 21448181›Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2011

Clinical implication of lung fluid balance in the perinatal period.

C Katz, L Bentur, N Elias

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Postnatal maximal weight loss, fluid administration, and outcomes in extremely preterm newborns.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Endocrine regulation of airway clearance inProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

C KatzPediatric Pulmonary Division, Meyer Children's Hospital of Haifa, Haifa, Israel.
L Bentur
N Elias

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At birth, lung fluid produced during fetal life must be cleared immediately and efficiently before the first breath takes place, in order for infants to achieve a normal and successful transition from prenatal to postnatal life. Postnatal lung fluid resorption is mediated through activation of airway epithelial sodium channels (ENaC). The observation that ENaC expression is a gestational age-dependent process contributes to our understanding of the development of respiratory distress in both term and preterm infants due to impaired clearing of fluid from their lungs. As fluid absorption, mediated by ENaC activity, in postnatal life has a significant biological role in preventing respiratory distress, any strategy that enhances ENaC activity can potentially help to decrease its incidence and associated morbidity.

Indexed as

Epithelial Sodium ChannelsRespiratory Distress Syndrome, NewbornAnimalsBetamethasoneFluid ShiftsGene ExpressionGestational AgeGlucocorticoidsHumansInfant, NewbornInfant, PrematureMiceMice, KnockoutParturitionPerinatal CareRespirationBetamethasoneEpithelial Sodium ChannelsGlucocorticoidsScnn1a protein, mouse

Identifiers

PMID21448181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.