ArticleThe EMBO journal2011
Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
- Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition.Nature communications · 2025Article
- SMARCA5-mediated chromatin remodeling is required for germinal center formation.The Journal of experimental medicine · 2024Article
- Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.Cells · 2023Article
- Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation.Frontiers in molecular neuroscience · 2021Article
- CORENup: a combination of convolutional and recurrent deep neural networks for nucleosome positioning identification.BMC bioinformatics · 2020Article
- ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.Frontiers in molecular neuroscience · 2019Article
- Deep learning architectures for prediction of nucleosome positioning from sequences data.BMC bioinformatics · 2018Article
- Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process.The Journal of biological chemistry · 2018Article
- Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair.Nature communications · 2017Article
- Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine.Neuroscience · 2017Article
- The ISWI remodeler in plants: protein complexes, biochemical functions, and developmental roles.Chromosoma · 2017Review
- SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.Genome research · 2016Article
- Dosage Compensation and the Distribution of Sex-Biased Gene Expression in Drosophila: Considerations and Genomic Constraints.Journal of molecular evolution · 2016Article
- Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators.PLoS genetics · 2016Article
- Facilitation of base excision repair by chromatin remodeling.DNA repair · 2015Review
- ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior.Nature medicine · 2015Article
- Active promoters give rise to false positive 'Phantom Peaks' in ChIP-seq experiments.Nucleic acids research · 2015Article
- Dosage compensation in Drosophila.Cold Spring Harbor perspectives in biology · 2015Review
- Brg1 modulates enhancer activation in mesoderm lineage commitment.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The evolutionarily conserved ATP-dependent nucleosome remodelling factor ISWI can space nucleosomes affecting a variety of nuclear processes. In Drosophila, loss of ISWI leads to global transcriptional defects and to dramatic alterations in higher-order chromatin structure, especially on the male X chromosome. In order to understand if chromatin condensation and gene expression defects, observed in ISWI mutants, are directly correlated with ISWI nucleosome spacing activity, we conducted a genome-wide survey of ISWI binding and nucleosome positioning in wild-type and ISWI mutant chromatin. Our analysis revealed that ISWI binds both genic and intergenic regions. Remarkably, we found that ISWI binds genes near their promoters causing specific alterations in nucleosome positioning at the level of the Transcription Start Site, providing an important insights in understanding ISWI role in higher eukaryote transcriptional regulation. Interestingly, differences in nucleosome spacing, between wild-type and ISWI mutant chromatin, tend to accumulate on the X chromosome for all ISWI-bound genes analysed. Our study shows how in higher eukaryotes the activity of the evolutionarily conserved nucleosome remodelling factor ISWI regulates gene expression and chromosome organization genome-wide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.