ArticleAntiviral therapy2011
Incident hyperglycaemia among older adults with or at-risk for HIV infection.
Article in Antiviral therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Article
- Prevalence and risk factors of high cholesterol and triglycerides among people with HIV in Texas.AIDS research and therapy · 2022Article
- Endocrinological aspects of HIV infection.Journal of endocrinological investigation · 2018Review
- Diabetes mellitus type 2 and abnormal glucose metabolism in the setting of human immunodeficiency virus.Endocrinology and metabolism clinics of North America · 2014Review
- The burden of diabetes and hyperlipidemia in treated HIV infection and approaches for cardiometabolic care.Current HIV/AIDS reports · 2012Review
- HIV infection and obesity: where did all the wasting go?Antiviral therapy · 2012Article
- Risk of diabetes mellitus in persons with and without HIV: a Danish nationwide population-based cohort study.PloS one · 2012Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundHIV infection has been associated with development of prediabetes and diabetes. Optimum screening practices for these disorders in HIV-infected populations remain unclear.
methodsWe screened 377 adults, with or at-risk for HIV infection, for incident hyperglycaemia (prediabetes or diabetes) using two oral glucose tolerance tests (OGTTs) a median of 18.6 months apart. We determined proportion of incident cases detected by fasting and 120-min plasma glucose levels. Independent predictors of incident hyperglycaemia were identified using logistic regression.
resultsThe baseline OGTT was consistent with diabetes in 7% of participants and with prediabetes in 31%. Among 352 normoglycaemic and prediabetic participants at baseline, 19 (5%) developed diabetes on follow-up. Among participants normoglycaemic at baseline, an additional 38 (16%) developed prediabetes. Overall 52% of incident hyperglycaemia cases were detected by fasting plasma glucose alone, 33% by a 120-min glucose level alone and 15% by both. Factors independently associated with incident hyperglycaemia included age ≥50 years and body mass index ≥30 kg/m(2). Neither HIV infection nor highly active antiretroviral therapy (HAART) use were associated with increased risk of diabetes.
conclusionsIncident hyperglycaemia is common among older adults with or at-risk for HIV infection. HIV-infected individuals with classic diabetes risk factors should be screened for hyperglycaemia regardless of HAART use. OGTTs might be the preferred screening strategy in HIV-infected individuals at high risk for developing hyperglycaemia.
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