ArticleInvestigative ophthalmology & visual science2011
Lamina-specific functional MRI of retinal and choroidal responses to visual stimuli.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Retinal tissue oxygen tension and consumption during light flicker stimulation in rat.Experimental eye research · 2018Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Impact of motion-associated noise on intrinsic optical signal imaging in humans with optical coherence tomography.Biomedical optics express · 2015Article
- Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Long-term effects of neonatal hypoxia-ischemia on structural and physiological integrity of the eye and visual pathway by multimodal MRI.Investigative ophthalmology & visual science · 2014Article
- Response of inner retinal oxygen extraction fraction to light flicker under normoxia and hypoxia in rat.Investigative ophthalmology & visual science · 2014Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading.Investigative ophthalmology & visual science · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Multiparametric optical coherence tomography imaging of the inner retinal hemodynamic response to visual stimulation.Journal of biomedical optics · 2013Article
- Postocclusive reactive hyperemia occurs in the rat retinal circulation but not in the choroid.Investigative ophthalmology & visual science · 2013Article
- MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.Experimental eye research · 2013Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres.Current eye research · 2013Article
- Effect of ultrasound radiation force on the choroid.Investigative ophthalmology & visual science · 2013Article
- Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.Magnetic resonance in medicine · 2012Article
- Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.Progress in retinal and eye research · 2012Review
- Layer-specific manganese-enhanced MRI of the retina in light and dark adaptation.Investigative ophthalmology & visual science · 2012Article
- Article
- 3D magnetic resonance microscopy of the ex vivo retina.Magnetic resonance in medicine · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo demonstrate lamina-specific functional magnetic resonance imaging (MRI) of retinal and choroidal responses to visual stimulation of graded luminance, wavelength, and frequency. MATERIALS AND
methodsHigh-resolution (60 × 60 μm) MRI was achieved using the blood-pool contrast agent, monocrystalline iron oxide nanoparticles (MION) and a high-magnetic-field (11.7 T) scanner to image functional changes in the normal rat retina associated with various visual stimulations. MION functional MRI measured stimulus-evoked blood-volume (BV) changes. Graded luminance, wavelength, and frequency were investigated. Stimulus-evoked fMRI signal changes from the retinal and choroidal vascular layers were analyzed.
resultsMRI revealed two distinct laminar signals that corresponded to the retinal and choroidal vascular layers bounding the retina and were separated by the avascular layer in between. The baseline outer layer BV index was 2-4 times greater than the inner layer BV, consistent with higher choroidal vascular density. During visual stimulation, BV responses to flickering light of different luminance, frequency, and wavelength in the inner layer were greater than those in the outer layer. The inner layer responses were dependent on luminance, frequency, and wavelength, whereas the outer layer responses were not, suggesting differential neurovascular coupling between the two vasculatures.
conclusionsThis is the first report of simultaneous resolution of layer-specific functional responses of the retinal and choroid vascular layers to visual stimulation in the retina. This imaging approach could have applications in early detection and longitudinal monitoring of retinal diseases where retinal and choroidal hemodynamics may be differentially perturbed at various stages of the diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.