ArticleDevelopment (Cambridge, England)2011
Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- MiR92b-3p synthetic analogue impairs zebrafish embryonic development, leading to ocular defects, decreased movement and hatching rate, and increased mortality.Journal of applied genetics · 2023Article
- Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models.Scientific reports · 2021Article
- From Endoderm to Progenitors: An Update on the Early Steps of Thyroid Morphogenesis in the Zebrafish.Frontiers in endocrinology · 2021Review
- Differential expression of microRNAs in the human fetal left and right cerebral cortex.Molecular biology reports · 2020Article
- Distinct expression patterns of seven crucial microRNAs during early embryonic development in medaka (Oryzias latipes).Gene expression patterns : GEP · 2020Article
- Small RNA Sequencing Reveals Regulatory Roles of MicroRNAs in the Development ofInternational journal of molecular sciences · 2019Article
- Epigenetic Regulation of Organ Regeneration in Zebrafish.Journal of cardiovascular development and disease · 2018Review
- Comparison of multi-lineage differentiation of hiPSCs reveals novel miRNAs that regulate lineage specification.Scientific reports · 2018Article
- miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.Developmental biology · 2017Article
- miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.Developmental biology · 2015Article
- Article
- MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1.Journal of cell science · 2014Article
- Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Celf1 is required for formation of endoderm-derived organs in zebrafish.International journal of molecular sciences · 2013Article
- Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.Development (Cambridge, England) · 2013Article
- Left-right asymmetry in zebrafish.Cellular and molecular life sciences : CMLS · 2012Review
- Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
microRNAs (miRNAs) are a family of 21-23 nucleotide endogenous non-coding RNAs that post-transcriptionally regulate gene expression in a sequence-specific manner. Typically, miRNAs downregulate target genes by recognizing and recruiting protein complexes to 3'UTRs, followed by translation repression or mRNA degradation. miR-92 is a well-studied oncogene in mammalian systems. Here, using zebrafish as a model system, we uncovered a novel tissue-inductive role for miR-92 during early vertebrate development. Overexpression resulted in reduced endoderm formation during gastrulation with consequent cardia and viscera bifida. By contrast, depletion of miR-92 increased endoderm formation, which led to abnormal Kupffer's vesicle development and left-right patterning defects. Using target prediction algorithms and reporter constructs, we show that gata5 is a target of miR-92. Alteration of gata5 levels reciprocally mirrored the effects of gain and loss of function of miR-92. Moreover, genetic epistasis experiments showed that miR-92-mediated defects could be substantially suppressed by modulating gata5 levels. We propose that miR-92 is a critical regulator of endoderm formation and left-right asymmetry during early zebrafish development and provide the first evidence for a regulatory function for gata5 in the formation of Kupffer's vesicle and left-right patterning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.