ArticleDevelopment (Cambridge, England)2011
The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.Frontiers in genetics · 2022Review
- GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells.Archives of virology · 2020Article
- TheCells · 2020Article
- Downregulation of homeodomain protein Cut is essential forDevelopment (Cambridge, England) · 2019Article
- DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation.EMBO reports · 2019Article
- DEAD-box RNA helicase Belle posttranscriptionally promotes gene expression in an ATPase activity-dependent manner.RNA (New York, N.Y.) · 2019Article
- IMP regulates Kuzbanian to control the timing of Notch signalling inDevelopment (Cambridge, England) · 2019Article
- The multiple functions of RNA helicases as drivers and regulators of gene expression.Nature reviews. Molecular cell biology · 2016Review
- RNA helicase Belle/DDX3 regulates transgene expression in Drosophila.Developmental biology · 2016Article
- Drosophila DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway.PloS one · 2016Article
- MicroRNA let-7b-regulated epidermal stem cell proliferation in hypertrophied anal papillae.Molecular medicine reports · 2015Article
- Enterovirus 71 induces apoptosis of SH‑SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.Molecular medicine reports · 2015Article
- MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells.PLoS genetics · 2015Article
- miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.Developmental biology · 2015Article
- Article
- E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.Journal of cell science · 2014Article
- Regulation of broad by the Notch pathway affects timing of follicle cell development.Developmental biology · 2014Article
- The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells.Development (Cambridge, England) · 2013Article
- Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.Developmental biology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Multicellular development requires the correct spatial and temporal regulation of cell division and differentiation. These processes are frequently coordinated by the activities of various signaling pathways such as Notch signaling. From a screen for modifiers of Notch signaling in Drosophila we have identified the RNA helicase Belle, a recently described component of the RNA interference pathway, as an important regulator of the timing of Notch activity in follicle cells. We found that loss of Belle delays activation of Notch signaling, which results in delayed follicle cell differentiation and defects in the cell cycle. Because mutations in well-characterized microRNA components phenocopied the Notch defects observed in belle mutants, Belle might be functioning in the microRNA pathway in follicle cells. The effect of loss of microRNAs on Notch signaling occurs upstream of Notch cleavage, as expression of the constitutively active intracellular domain of Notch in microRNA-defective cells restored proper activation of Notch. Furthermore, we present evidence that the Notch ligand Delta is an important target of microRNA regulation in follicle cells and regulates the timing of Notch activation through cis inhibition of Notch. Here we have uncovered a complex regulatory process in which the microRNA pathway promotes Notch activation by repressing Delta-mediated inhibition of Notch in follicle cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.