ReviewDiscovery medicine2011
Temperatures rising: brown fat and bone.
Review in Discovery medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT.Histology and histopathology · 2022Article
- Article
- Brown Fat Promotes Muscle Growth During Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Congenital lipodystrophy induces severe osteosclerosis.PLoS genetics · 2019Article
- Low temperature decreases bone mass in mice: Implications for humans.American journal of physical anthropology · 2018Article
- Sexual Dimorphism and the Origins of Human Spinal Health.Endocrine reviews · 2018Review
- Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice.The Journal of endocrinology · 2016Article
- Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.Endocrinology · 2016Article
- Brown adipose tissue and bone.International journal of obesity supplements · 2015Review
- Body composition during childhood and adolescence: relations to bone strength and microstructure.The Journal of clinical endocrinology and metabolism · 2014Article
- What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health.Annals of the New York Academy of Sciences · 2014Review
- Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.Cell metabolism · 2014Article
- Article
- Altered thermogenesis and impaired bone remodeling in Misty mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Article
- Review
- Brown adipose tissue and its relationship to bone structure in pediatric patients.The Journal of clinical endocrinology and metabolism · 2012Article
- Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women.The Journal of clinical endocrinology and metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Caloric restriction is associated with a reduction in body weight and temperature, as well as a reduction in trabecular bone volume and paradoxically an increase in adipocytes within the bone marrow. The nature of these adipocytes is uncertain, although there is emerging evidence of a direct relationship between bone remodeling and brown adipocytes. For example, in heterotrophic ossification, brown adipocytes set up a hypoxic gradient that leads to vascular invasion, chondrocyte differentiation, and subsequent bone formation. Additionally, deletion of retinoblastoma protein in an osteosarcoma model leads to increased hibernoma (brown fat tumor). Brown adipose tissue (BAT) becomes senescent with age at a time when thermoregulation is altered, bone loss becomes apparent, and sympathetic activity increases. Interestingly, heart rate is an unexpected but good predictor of fracture risk in elderly individuals, pointing to a key role for the sympathetic nervous system in senile osteoporosis. Hence the possibility exists that BAT could play an indirect role in age-related bone loss. However, evidence of an indirect effect from thermogenic dysfunction on bone loss is currently limited. Here, we present current evidence for a relationship between brown adipose tissue and bone as well as provide novel insights into the effects of thermoregulation on bone mineral density.
Indexed as
Identifiers
21447277PMC3629549W1571186106What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.