ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2011
Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies.Molecular psychiatry · 2013Pooled it
- Excitatory Amino Acid Transporters as Therapeutic Targets in the Treatment of Neurological Disorders: Their Roles and Therapeutic Prospects.Neurochemical research · 2025Review
- Advancing Obsessive-Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies.Brain sciences · 2025Review
- Forebrain EAAT3 Overexpression Increases Susceptibility to Amphetamine-Induced Repetitive Behaviors.eNeuro · 2024Article
- Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients.Frontiers in psychiatry · 2023Review
- Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder.Translational psychiatry · 2021Article
- Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum in an initial study of subjects with obsessive compulsive disorder.Molecular psychiatry · 2021Article
- Astroglia and Obsessive Compulsive Disorder.Advances in neurobiology · 2021Article
- Association Between theNeuropsychiatric disease and treatment · 2021Article
- Genetic Association of Epilepsy and Anti-Epileptic Drugs Treatment in Jordanian Patients.Pharmacogenomics and personalized medicine · 2020Article
- Do polygenic risk and stressful life events predict pharmacological treatment response in obsessive compulsive disorder? A gene-environment interaction approach.Translational psychiatry · 2019Article
- Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease.Neurochemistry international · 2019Article
- The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder.Frontiers in pharmacology · 2019Review
- An MRI Study of the Metabolic and Structural Abnormalities in Obsessive-Compulsive Disorder.Frontiers in human neuroscience · 2019Article
- Genetics of obsessive-compulsive disorder.Indian journal of psychiatry · 2019Review
- Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach.European archives of psychiatry and clinical neuroscience · 2018Article
- Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population.PloS one · 2018Article
- Rare SLC1A1 variants in hot water epilepsy.Human genetics · 2017Article
- OCD candidate geneProceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
19 authors at 11 institutions in 1 country.
Funding
Abstract
SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessive-compulsive disorder (OCD). Several independent research groups have reported significant associations between OCD and single nucleotide polymorphisms (SNPs) in this gene. Previously, we evaluated 13 SNPs in, or near, SLC1A1 and reported a strong association signal with rs301443, a SNP 7.5 kb downstream of the gene [Shugart et al. (2009); Am J Med Genet Part B 150B:886–892]. The aims of the current study were first, to further investigate this finding by saturating the region around rs301443; and second, to explore the entire gene more thoroughly with a dense panel of SNP markers. We genotyped an additional 111 SNPs in or near SLC1A1, covering from 9 kb upstream to 84 kb downstream of the gene at average spacing of 1.7 kb per SNP, and conducted family-based association analyses in 1,576 participants in 377 families.We found that none of the surrounding markers were in linkage disequilibrium with rs301443, nor were any associated with OCD. We also found that SNP rs4740788, located about 8.8 kb upstream of the gene, was associated with OCD in all families (P = 0.003) and in families with male affecteds (P = 0.002). A three-SNP haplotype (rs4740788–rs10491734–rs10491733) was associated with OCD in the total sample (P = 0.00015) and in families with male affecteds (P = 0.0007). Although of nominal statistical significance considering the number of comparisons, these findings provide further support for the involvement of SLC1A1 in the pathogenesis of OCD.
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