ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2011
Local tissue properties of human osteoarthritic cartilage correlate with magnetic resonance T(1) rho relaxation times.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2019Pooled it
- Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping.Journal of biomechanics · 2021Article
- Bi-component T2 mapping correlates with articular cartilage material properties.Journal of biomechanics · 2021Article
- Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.Journal of biomechanics · 2020Article
- Determination of the Depth- and Time- Dependent Mechanical Behavior of Mouse Articular Cartilage Using Cyclic Reference Point Indentation.Cartilage · 2020Article
- Rapid determination of internal strains in soft tissues using an experimentally calibrated finite element model derived from magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2020Article
- TQuantitative imaging in medicine and surgery · 2019Article
- Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times.Annals of biomedical engineering · 2019Article
- In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking.The American journal of sports medicine · 2017Article
- Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage.Journal of biomechanics · 2017Article
- T1ρ magnetic resonance: basic physics principles and applications in knee and intervertebral disc imaging.Quantitative imaging in medicine and surgery · 2015Review
- T1ρ Dispersion in Articular Cartilage: Relationship to Material Properties and Macromolecular Content.Cartilage · 2015Article
- Cartilage MRI relaxation times after arthroscopic partial medial meniscectomy reveal localized degeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning.Journal of biomechanical engineering · 2013Review
- Imaging biopsy composition at ACL reconstruction.Orthopedic research and reviews · 2013Article
- Effects of unloading on knee articular cartilage T1rho and T2 magnetic resonance imaging relaxation times: a case series.The Journal of orthopaedic and sports physical therapy · 2012Article
- The use of polyacrylamide gels for mechanical calibration of cartilage--a combined nanoindentation and unconfined compression study.Journal of the mechanical behavior of biomedical materials · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this study is to examine the local relationship between T(1ρ) relaxation times and the mechanical behavior of human osteoarthritic articular cartilage using high-resolution magnetic resonance imaging (MRI) and local in situ microindentation. Seven human tibial plateaus were obtained from patients who underwent total knee arthroplasty due to severe osteoarthritis (OA). Three to six sites were selected from each sample for visual classification using the ICRS Outerbridge scale (a total of 36 sites). Samples were imaged by MR, and the local distribution of T(1ρ) relaxation times were obtained at these selected sites. The elastic and viscoelastic characteristics of the tissue were quantified nondestructively using dynamic microindentation to measure peak dynamic modulus, energy dissipation, and phase angle. Measured Outerbridge scores, MR T(1ρ) relaxation times, and mechanical properties were highly heterogeneous across each cartilage surface. Site-specific measures of T(1ρ) relaxation times correlated significantly with the phase angle (p < 0.001; R = 0.908), a viscoelastic mechanical behavior of the cartilage. The novel combination of high-resolution MR imaging and microindentation allows the investigation of the local relationship between quantitative MRI and biomechanical properties in highly heterogeneous OA cartilage. These findings suggest that MRI T(1ρ) can provide a functional assessment of articular cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.