ArticleAdvances in experimental medicine and biology2011
Fetal cerebral oxygenation: the homeostatic role of vascular adaptations to hypoxic stress.
Article in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Transitional haemodynamic profiles of intrauterine growth-restricted preterm infants: correlation with antenatal Doppler characteristics.Pediatric research · 2025Article
- The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period.Frontiers in neuroscience · 2019Review
- Brain oxygenation declines in elite Kenyan runners during a maximal interval training session.European journal of applied physiology · 2017Article
- Role of the sympathetic autonomic nervous system in hypoxic remodeling of the fetal cerebral vasculature.Journal of cardiovascular pharmacology · 2015Review
- The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.Advances in experimental medicine and biology · 2014Article
- Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.PloS one · 2014Article
- Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian fetus is highly adapted for growth in a low-O(2) environment in which arterial O(2) tensions average near 30 mm Hg. Acute decreases in O(2) tension below this value elicit vasodilatation, but the responses are blunted compared to those observed in adults. Chronic hypoxia in the fetus stimulates a pattern of cerebrovascular remodeling that results in an increased wall thickness and decreased overall contractility and also depresses the capacity for cerebral vasodilatation through decreases in NO release, soluble guanylate cyclase activity, and expression of PKG substrates. Many of these hypoxic effects appear to be homeostatic and may be mediated by VEGFs, which increase in direct response to hypoxia and, in turn, can dramatically alter the expression and function of multiple contractile proteins in cerebrovascular smooth muscle through both endothelium-dependent and endothelium-independent effects on large artery smooth muscle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.