ArticleAdvances in experimental medicine and biology2011
Characterizing breast cancer mouse xenografts with T₁ρ -MRI: a preliminary study.
Article in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease.NeuroImage. Clinical · 2015Article
- The interaction between LYVE-1 with hyaluronan on the cell surface may play a role in the diversity of adhesion to cancer cells.PloS one · 2013Article
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3 authors.
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Abstract
Previously three imaging methods, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), T(1ρ )-MRI, and low temperature NADH/Fp (reduced nicotinamide adenine dinucleotide/oxidized flavoprotein) fluorescence imaging (redox scanning)were reported to differentiate the mouse xenografts of a less metastatic human melanoma cell line A375P and a more metastatic line C8161. The more metastatic melanoma is characterized by less blood perfusion/permeability and more oxidized mitochondrial redox state in the tumor core and lower T(1ρ ) relaxation time averaged across the tumor section. These features may be useful for identifying imaging biomarkers for cancer metastatic potential. Here, we have employed T(1ρ )- and T2-weighted MRI to image mouse xenografts of two human breast cancer lines (more metastatic MDA-MB-231 and less metastatic MDA-MB-468) on a vertical bore 9.4- T Varian MR system. The preliminary results indicated that the more metastatic MDA-MB-231 tumors had shorter T(xρ ) relaxation constants on average than the less metastatic MDA-MB-468 tumors, and T(xρ ) relaxation might be a potential biomarker of breast tumor metastatic potential. Distinct ring-like structures were observed on T(xρ )-weighted MR images of the breast tumors, indicating tumor core and rim difference. This observation appears to be consistent with the tumor core-rim difference previously observed by DCE-MRI and redox scanning on aggressive melanoma xenografts.
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