ArticleJournal of pharmacokinetics and pharmacodynamics2011
A Bayesian approach for the estimation of patient compliance based on the last sampling information.
Article in Journal of pharmacokinetics and pharmacodynamics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Population pharmacokinetics of tenofovir and tenofovir-diphosphate in healthy women.Journal of clinical pharmacology · 2015Trial
- Estimation of tenofovir's population pharmacokinetic parameters without reliable dosing histories and application to tracing dosing history using simulation strategies.Journal of clinical pharmacology · 2014Trial
- Bayesian-Based Pharmacokinetic Framework Integrated with Therapeutic Drug Monitoring for Assessing Adherence to Antiseizure Medications: A Clinical Trial Simulation Study.Journal of medical Internet research · 2026Article
- Commentary: Awareness, use, attitudes, and implementation challenges of Bayesian dose prediction software in clinical practice: a multi-organizational survey.Frontiers in pharmacology · 2026Article
- Medication adherence framework: A population-based pharmacokinetic approach and its application in antimalarial treatment assessments.CPT: pharmacometrics & systems pharmacology · 2024Article
- Response to "Pharmacometric Approach to Evaluate Drug Dosing Adherence".Clinical pharmacology and therapeutics · 2021Article
- Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children.Clinical pharmacology and therapeutics · 2020Article
- Effect of Adherence on Pharmacokinetic/Pharmacodynamic Relationships of Oral Targeted Anticancer Drugs.Clinical pharmacokinetics · 2018Article
- Variability and singularity arising from poor compliance in a pharmacokinetic model II: the multi-oral case.Journal of mathematical biology · 2017Article
- Methods to detect non-compliance and reduce its impact on population PK parameter estimates.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Compliance spectrum as a drug fingerprint of drug intake and drug disposition.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- Variability and singularity arising from poor compliance in a pharmacokinetic model I: the multi-IV case.Journal of pharmacokinetics and pharmacodynamics · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Poor adherence to a drug prescription significantly impacts on the efficacy and safety of a planned therapy. The relationship between drug intake and pharmacokinetics (PK) is only partially known. In this work, we focus on the so-called "inverse problem", concerned with the issue of retracing the patient compliance scenario using limited clinical knowledge. Using a reported Pop-PK model of imatinib, and accounting for the variability around its PK parameters, we were able to simulate a whole range of drug concentration values at a specific sampling point for a population of patients with all possible drug compliance profiles. Using a Bayesian decision rule, we developed a methodology for the determination of the associated compliance profile prior to a given sampling value. The adopted approach allows, for the first time, to quantitatively acquire knowledge about the compliance patterns having a causal effect on a given PK. Moreover, using a simulation approach, we were able to evaluate the evolution of success rate of the retracing process in terms of the considered time period before sampling as well as the model-inherited variability. In conclusion, this work allows, from a probability viewpoint, to propose a solution for this inverse problem of compliance determination.
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Registered trials
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