ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
Analysis of sequential cytokine release after ACL reconstruction.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Changes in circulating biomarkers of muscle atrophy, inflammation, and cartilage turnover in patients undergoing anterior cruciate ligament reconstruction and rehabilitation.The American journal of sports medicine · 2013Trial
- Synovial Fluid Biomarkers Associated With Anterior Cruciate Ligament Injury and Reconstruction: A Systematic Review.Orthopaedic journal of sports medicine · 2026Review
- Efficacy of Fibrin Clot Implantation for Reduction of Bone Tunnel Enlargement in Double-Bundle ACL Reconstruction Using Autogenous Hamstring Graft.Orthopaedic journal of sports medicine · 2025Article
- Distinct patterns of cytokines, chemokines, and growth factors in synovial fluid after ACL injury in comparison to osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Association of Infrapatellar Fat Pad Fibrosis at 3 Months After ACL Reconstruction With Short-term Clinical Outcomes and Inflammatory Cytokine Levels in the Synovial Fluid.Orthopaedic journal of sports medicine · 2023Article
- Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries.Arthritis research & therapy · 2021Article
- Phosphorylated Platelet-Derived Growth Factor Receptor-Positive Cells With Anti-apoptotic Properties Accumulate in the Synovium of Patients With Rheumatoid Arthritis.Frontiers in immunology · 2019Article
- Effects of Remnant Tissue Preservation on Tunnel Enlargement After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using the Hamstring Tendon.Orthopaedic journal of sports medicine · 2018Article
- Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery.The American journal of sports medicine · 2018Article
- Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Articular cartilage status 2 years after arthroscopic ACL reconstruction in patients with or without concomitant meniscal surgery: evaluation with 3.0T MR imaging.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury.BMC musculoskeletal disorders · 2016Article
- Why menisci show higher healing rate when repaired during ACL reconstruction? Growth factors release can be the explanation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model.Journal of inflammation (London, England) · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRupture of the anterior cruciate ligament is common and may necessitate surgical reconstruction. Surgical reconstruction aims to restore normal kinematics and biology within the knee. The acute phase response after surgical reconstruction remains poorly defined but may influence graft integration through modulation of host tissue remodelling.
methodsThe very early host production of key cytokines after surgery was studied. A consecutive series of 14 patients undergoing reconstructive surgery were studied per-operatively, 1 and 6 h after surgery, examining the hypothesis that the acute phase response would be non-specific but consistent between individuals, demonstrating increases of pro-inflammatory cytokines.
resultsA consistent increased release of monocyte-driven, non-specific, IL-1 and IL-6 release but not T cell-derived IL-2 was found. Perhaps, more interestingly, very early high concentrations of secondary growth factors PDGF and TGF-β suggestive of an anabolic response were found.
conclusionThese data support the contention that an anabolic response starts earlier than previously thought within the surgically reconstructed knee.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.