Evidence map›Paper›PMID 21445582›Full record

ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2011

Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism.

Norman J Haughey, Luis B Tovar-y-Romo, Veera Venkata Ratnam Bandaru

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cell signaling pathways and HIV-1 therapeutics.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Norman J HaugheyDepartment of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600N. Wolfe Street, Baltimore, MD 21287, USA. nhaughe1@jhmi.edu
Luis B Tovar-y-Romo
Veera Venkata Ratnam Bandaru
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Mechanisms of Neuroinflammation in HANDR01MH077542 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2007 to 2016
$3.4M
Interaction of Alcohol with HIV-ProteinR01AA017408 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2007 to 2011
$1.9M
HIV Associated CNS Dysfunction with AgingR01AG023471 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2003 to 2007
$1.8M
Perturbation of amyloid processing in HANDR21AG034849 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGHEY, NORMAN J · 2010 to 2011
$377k
NIAAA NIH HHS AA017408NIAAA NIH HHS R01 AA017408NIA NIH HHS AG034849NIA NIH HHS R01 AG023471NIA NIH HHS R21 AG034849NIMH NIH HHS MH077542NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH077542
6 · The paper itself

Abstract

Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.

Indexed as

AnimalsAnti-HIV AgentsDrug Delivery SystemsHIVHIV-1HIV InfectionsHumansLipid MetabolismMembrane LipidsMembrane MicrodomainsVirus ReplicationAnti-HIV AgentsMembrane Lipids

Identifiers

PMID21445582
PMCPMC3417146
OpenAlexW1964693949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.