ArticleLab on a chip2011
A membrane-based, high-efficiency, microfluidic debubbler.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective.Biomicrofluidics · 2023Article
- A Scalable, Modular Degasser for Passive In-Line Removal of Bubbles from Biomicrofluidic Devices.Micromachines · 2023Article
- A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient.Science advances · 2022Article
- Microfluidic Continuous Flow DNA Fragmentation based on a Vibrating Sharp-tip.Microfluidics and nanofluidics · 2022Article
- Air bubble removal: Wettability contrast enabled microfluidic interconnects.Sensors and actuators. B, Chemical · 2022Article
- Emergence of debubblers in microfluidics: A critical review.Biomicrofluidics · 2022Review
- A bioinspired bubble removal method in microchannels based on angiosperm xylem embolism repair.Microsystems & nanoengineering · 2022Article
- An integrated microfluidic bubble pocket for long-term perfused three-dimensional intestine-on-a-chip model.Biomicrofluidics · 2021Article
- 3D-Printed Bubble-Free Perfusion Cartridge System for Live-Cell Imaging.Sensors (Basel, Switzerland) · 2020Article
- Liquid seal for compact micropiston actuation at the capillary tip.Science advances · 2020Article
- A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.Lab on a chip · 2020Article
- Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device.Lab on a chip · 2020Article
- A Low-Cost, Rapidly Integrated Debubbler (RID) Module for Microfluidic Cell Culture Applications.Micromachines · 2019Article
- Automatic sequential fluid handling with multilayer microfluidic sample isolated pumping.Biomicrofluidics · 2015Article
- Liquid-based gating mechanism with tunable multiphase selectivity and antifouling behaviour.Nature · 2015Article
- A micropillar array for sample concentration via in-plane evaporation.Biomicrofluidics · 2014Article
- Bubble-free and pulse-free fluid delivery into microfluidic devices.Biomicrofluidics · 2014Article
- Membrane-based, sedimentation-assisted plasma separator for point-of-care applications.Analytical chemistry · 2013Article
- Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field.Analytical chemistry · 2013Review
- CO(2) dissolution in water using long serpentine microchannels.Biomicrofluidics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In many lab-on-chip applications, it is necessary to remove bubbles from the flow stream. Existing bubble removal strategies have various drawbacks such as low degassing efficiency, long degassing time, large dead volumes, sensitivity to surfactants, and the need for an external vacuum or pressure source. We report on a novel, simple, robust, passive, nozzle-type, membrane-based debubbler that can be readily incorporated into microfluidic devices for rapid degassing. The debubbler is particularly suitable to operate with microfluidic systems made with plastic. The debubbler consists of a hydrophobic, porous membrane that resembles a normally closed valve, which is forced open by the working fluid's pressure. To illustrate the operation of the debubbler, we describe its use in the context of a chip containing a bead array for immunoassays. Our debubbler was able to completely filter gas bubbles out of a segmented flow at rates up to 60 µl s(-1) mm(-2) of membrane area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.