ArticlePloS one2011
Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the Landscape of Global Anticancer Organometallics Research: A Systematic Review.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025Pooled it
- Ti(IV) Asymmetric Acetyl-Substituted Phenolato Hexacoordinate Complexes as Anticancer Chemotherapy of Enhanced Bioavailability.ChemMedChem · 2026Article
- Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.Journal of medicinal chemistry · 2024Article
- A Comprehensive Review on the Development of Titanium Complexes as Cytotoxic Agents.Current topics in medicinal chemistry · 2024Review
- Structural Speciation of Ti(IV)-(α-Hydroxycarboxylic Acid) Complexes in Metabolism-Related (Patho)Physiology-In Vitro Approaches to (Pre)Adipocyte Differentiation and Mineralization.International journal of molecular sciences · 2023Article
- Hydrolytically Stable and Cytotoxic [ONOInorganic chemistry · 2022Article
- A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway.Journal of cancer research and clinical oncology · 2021Article
- Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their CDalton transactions (Cambridge, England : 2003) · 2021Article
- Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug.iScience · 2020Article
- RacemicRSC advances · 2018Article
- In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs.ChemMedChem · 2018Article
- Synthesis of Pure Enantiomers of Titanium(IV) Complexes with Chiral Diaminobis(phenolato) Ligands and Their Biological Reactivity.Scientific reports · 2018Article
- Differential cytotoxicity induced by the Titanium(IV)Salan complex Tc52 in G2-phase independent of DNA damage.BMC cancer · 2016Article
- Comparative In Vitro Binding Studies of TiCl2(dpme)2, Ti(ada)2(bzac)2, and TiCl2(bzac)(bpme) Titanium Complexes with Calf-Thymus DNA.Biochemistry research international · 2015Article
- Cytotoxicity of a Ti(IV) compound is independent of serum proteins.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells.Gynecologic oncology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
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