ArticlePloS one2011
Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery after spinal cord injury in mice.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Cell transplantation for spinal cord injury: a systematic review.BioMed research international · 2013Pooled it
- The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.International journal of molecular sciences · 2023Article
- COVID-19 disease treatment: pivotal challenges in the arena of umbilical cord-mesenchymal stem cells (UC-MSCs).Frontiers in cell and developmental biology · 2023Review
- Artemisinin upregulates neural cell adhesion molecule L1 to attenuate neurological deficits after intracerebral hemorrhage in mice.Brain and behavior · 2022Article
- Antagonistic L1 Adhesion Molecule Mimetic Compounds Inhibit Glioblastoma Cell Migration In Vitro.Biomolecules · 2022Article
- Repair of the Injured Spinal Cord by Schwann Cell Transplantation.Frontiers in neuroscience · 2022Review
- Review
- Anisotropic scaffolds for peripheral nerve and spinal cord regeneration.Bioactive materials · 2021Review
- Proteomic Analysis of Preoperative CSF Reveals Risk Biomarkers of Postoperative Delirium.Frontiers in psychiatry · 2020Article
- Confocal Synaptology: Synaptic Rearrangements in Neurodegenerative Disorders and upon Nervous System Injury.Frontiers in neuroanatomy · 2018Review
- A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish.Molecular neurobiology · 2018Article
- Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion.Frontiers in pharmacology · 2017Article
- Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy.Biomaterials · 2017Article
- Small Molecule Agonists of Cell Adhesion Molecule L1 Mimic L1 Functions In Vivo.Molecular neurobiology · 2016Article
- Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.Molecular neurobiology · 2016Article
- The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair.Scientific reports · 2016Article
- Human Embryonic Stem Cell Therapy in Chronic Spinal Cord Injury: A Retrospective Study.Clinical and translational science · 2016Article
- The emerging roles of transplanted radial glial cells in regenerating the central nervous system.Neural regeneration research · 2015Article
- Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions.Stem cells international · 2015Review
- Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injury.Neural regeneration research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An obstacle to early stem cell transplantation into the acutely injured spinal cord is poor survival of transplanted cells. Transplantation of embryonic stem cells as substrate adherent embryonic stem cell-derived neural aggregates (SENAs) consisting mainly of neurons and radial glial cells has been shown to enhance survival of grafted cells in the injured mouse brain. In the attempt to promote the beneficial function of these SENAs, murine embryonic stem cells constitutively overexpressing the neural cell adhesion molecule L1 which favors axonal growth and survival of grafted and imperiled cells in the inhibitory environment of the adult mammalian central nervous system were differentiated into SENAs and transplanted into the spinal cord three days after compression lesion. Mice transplanted with L1 overexpressing SENAs showed improved locomotor function when compared to mice injected with wild-type SENAs. L1 overexpressing SENAs showed an increased number of surviving cells, enhanced neuronal differentiation and reduced glial differentiation after transplantation when compared to SENAs not engineered to overexpress L1. Furthermore, L1 overexpressing SENAs rescued imperiled host motoneurons and parvalbumin-positive interneurons and increased numbers of catecholaminergic nerve fibers distal to the lesion. In addition to encouraging the use of embryonic stem cells for early therapy after spinal cord injury L1 overexpression in the microenvironment of the lesioned spinal cord is a novel finding in its functions that would make it more attractive for pre-clinical studies in spinal cord regeneration and most likely other diseases of the nervous system.
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