Trial reportPloS one2011
Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the International Stroke Trial.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Prevalence, Trajectory, and Factors Associated With Patient-Reported Nonmotor Outcomes After Stroke: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Current Status of Barriers to mHealth Access Among Patients With Stroke and Steps Toward the Digital Health Era: Systematic Review.JMIR mHealth and uHealth · 2024Pooled it
- Related risk factors associated with post-stroke fatigue: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Pooled it
- Psychological associations of poststroke fatigue: a systematic review and meta-analysis.Stroke · 2014Pooled it
- Can patient-reported outcome measures predict mortality in neurological populations? A systematic review.Frontiers in neurologyPooled it
- ESTREL-Fatigue-association of levodopa with post-stroke fatigue.European stroke journal · 2026Trial
- Fluoxetine to improve functional outcomes in patients after acute stroke: the FOCUS RCT.Health technology assessment (Winchester, England) · 2020Trial
- Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial.Lancet (London, England) · 2019Trial
- Trial
- Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The relationship between post-stroke fatigue and trunk impairment in the subacute phase: a cross-sectional study.Journal of physical therapy science · 2026Article
- Physical Activity Interventions for Patients With Poststroke Fatigue: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Post-stroke fatigue and its consequences in young adults: The Norwegian Stroke in the Young Study II.eNeurologicalSci · 2025Article
- Dysphagia increases the risk of post-stroke fatigue.European journal of neurology · 2025Article
- Association between sleep-disordered breathing and post-stroke fatigue in patients with ischemic stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Fatigue after spontaneous intracerebral haemorrhage: prevalence and associated factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- Neuroimaging of neuropsychological disturbances following ischaemic stroke (CONNECT): a prospective cohort study protocol.BMJ open · 2024Article
- Post-stroke fatigue: a review of development, prevalence, predisposing factors, measurements, and treatments.Frontiers in neurology · 2023Review
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
background and purposeLittle is known about the associations of post-stroke fatigue or its influence on survival. The vitality component of the Short Form 36 (SF-36) is a valid and reliable measure of post-stroke fatigue. We sought to identify associates of post-stroke fatigue and determine whether fatigue predicted survival.
methodsWe used SF-36 vitality scores obtained by postal questionnaires from 1080 UK patients randomised in the International Stroke Trial, at a mean of 64 weeks after stroke onset. We used logistic regression to explore factors at randomisation which predicted SF-36 vitality at follow-up, and the relationship between SF-36 vitality and both SF-36 mental health and SF-36 emotional role function at follow-up. We used Cox proportional hazards to explore the influence of SF-36 vitality at follow-up on subsequent survival, using four different statistical models for handling missing data.
resultsFemale sex, increasing age, lower mental health and lower emotional role function scores were associated with greater degrees of fatigue after stroke (i.e. lower vitality scores) but these factors explained <30% of the variance (R(2)) in fatigue. In two models, fatigue at follow-up was associated with shorter subsequent survival.
conclusionIncreasing age, female sex, emotional role function and mental health were associated with increased fatigue at a mean of 64 weeks after stroke onset, but explained less than 30% of the variance. Fatigue was associated with reduced subsequent long-term survival in 2/4 models. Further work is needed to identify the biological substrate of fatigue and to clarify its influence on survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.