TDP-43: multiple targets, multiple disease mechanisms?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. TDP-43 safeguards the embryo genome from L1 retrotransposition.Science advances · 2022
   Article
2. A circular RNA generated from an intron of the insulin gene controls insulin secretion.Nature communications · 2020
   Article
3. Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.Mobile DNA · 2018
   Article
4. Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1.Nucleic acids research · 2014
   Article
5. Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.Human molecular genetics · 2013
   Article
6. Inhibition of TDP-43 aggregation by nucleic acid binding.PloS one · 2013
   Article
7. Transposable elements in TDP-43-mediated neurodegenerative disorders.PloS one · 2012
   Article
8. ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.Human molecular genetics · 2012
   Article
9. Next-generation sequencing reveals HIV-1-mediated suppression of T cell activation and RNA processing and regulation of noncoding RNA expression in a CD4+ T cell line.mBio · 2011
   Article

Corrections and comments

• Comment on
  Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.2011
• Comment on
  Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.2011

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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