ArticleHypertension (Dallas, Tex. : 1979)2011
Arterial stiffness, physical function, and functional limitation: the Whitehall II Study.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 102 citations in OpenAlex.
- Trial
- A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD.International journal of chronic obstructive pulmonary disease · 2017Trial
- GOLD 2026 COPD ABE assessment tool to identify individuals at high risk in a UK multicentre COPD cohort (ERICA).BMJ open respiratory research · 2026Article
- Hemodynamic Stress as a Cause of the High Prevalence of Arterial Disease in Women.Journal of vascular research · 2026Review
- Pulse wave velocity is elevated in people with serious mental illness with vascular age advanced in two-thirds of individuals.Cardiovascular endocrinology & metabolism · 2026Article
- Association of bioimpedance-derived parameters with pulse wave velocity: Phase angle, extracellular to intracellular water ratio, and body cell mass.Physiological reports · 2025Article
- Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study.The journal of nutrition, health & aging · 2024Article
- A Low Arginine/Ornithine Ratio is Associated with Long-Term Cardiovascular Mortality.Journal of atherosclerosis and thrombosis · 2023Article
- Association Between Pulse Wave Velocity and Frailty, Disability, and Mortality in Community-Dwelling Older Adults.JACC. Advances · 2023Article
- Arterial stiffness and augmentation index are associated with balance function in young adults.European journal of applied physiology · 2023Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Sex-specific associations between cardiovascular risk factors and physical function: the Gambian Bone and Muscle Ageing Study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Aortic Pulse Wave Velocity as Adjunct Risk Marker for Assessing Cardiovascular Disease Risk: Prospective Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study.Respiratory research · 2022Article
- Association of Arterial Stiffness with Functional Disability and Mobility Limitation: The Rugao Longitudinal Ageing Study.The journal of nutrition, health & aging · 2022Article
- A Nomogram for Predicting the Risk of Critical Limb Ischemia in Adults with Hypertension: A Retrospective Study.International journal of general medicine · 2022Article
- Diurnal pattern of salivary cortisol and progression of aortic stiffness: Longitudinal study.Psychoneuroendocrinology · 2021Article
- Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study.PLoS medicine · 2020Observational
- An analysis of vascular properties using pulse wave analysis in patients with vasovagal syncope.Clinical cardiology · 2020Article
- Poor Walking Speed Is Associated With Higher Segment-Specific Arterial Stiffness in Older Adult Japanese Community Dwellers: A Cross-Sectional Study.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Arterial stiffness has been proposed as an indicator of vascular aging. We aimed to examine this concept by analyzing associations of arterial stiffness with age, subjective and objective measures of physical functioning, and self-reported functional limitation. We measured aortic pulse wave velocity by applanation tonometry among 5392 men and women aged 55 to 78 years. Arterial stiffness was strongly associated with age (mean difference [SE] per decade: men, 1.37 m/s [0.06 m/s]; women: 1.39 m/s [0.10 m/s]). This association was robust to individual and combined adjustment for pulse pressure, mean arterial pressure, antihypertensive treatment, and chronic disease. Participants took an 8.00-ft (2.44-m) walking speed test, a spirometry lung function test, and completed health functioning and (instrumental) activities of daily living questionnaires. Associations of stiffness and blood pressure with physical function scores scaled to SD of 10 were compared. One-SD higher stiffness was associated with lower walking speed (coefficient [95% CI]: -0.96 [-1.29 to -0.64] m/s) and physical component summary score (-0.91 [-1.21 to -0.60]) and poorer lung function (-1.23 [-1.53 to -0.92] L) adjusted for age, sex, and ethnic group. Pulse pressure and mean arterial pressure were linked inversely only with lung function. Associations of stiffness with functional limitation were robust to multiple adjustment, including pulse pressure and chronic disease. In conclusion, the concept of vascular aging is reinforced by the observation that arterial stiffness is a robust correlate of physical functioning and functional limitation in early old age. The nature of the link between arterial stiffness and quality of life in older people merits attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.