ArticleProceedings of the National Academy of Sciences of the United States of America2011
Virophage control of antarctic algal host-virus dynamics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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Who cites it
150 citing papers in PubMed, 291 citations in OpenAlex.
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- Giant viruses of the polar regions: diversity, endemism, adaptation and ecological structuring.FEMS microbiology ecology · 2026Review
- Pantanal virophage: a new virophage species associated with a moumouvirus and a transpoviron, expanding the genusJournal of virology · 2026Article
- Uncovering novel virophages and giant viruses in high-altitude Lake Namtso: diversity and evolution of host-virus-virophage tripartite interaction systems.Archives of microbiology · 2026Article
- Microalga-virus-virophage coculture reveals co-infection of multi-virophages with a giant virus.Archives of virology · 2026Article
- A Polinton-like Virus ofViruses · 2026Article
- Illuminating the newly produced viruses within the virosphere with bioorthogonal noncanonical amino acid tagging and single-virus genomic sequencing technologies.ISME communications · 2026Article
- Conserved tripartite tail proteins mediate virophage-host interactions throughJournal of virology · 2025Article
- Identification and profiling of novel metagenome assembled uncultivated virus genomes from human gut.Virology journal · 2025Article
- Lineage-specific expansions of polinton-like viruses in photosynthetic cryptophytes.Microbiome · 2025Article
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- Vertical transport and spatiotemporal dynamics of giant viruses in the North Pacific subtropical gyre.The ISME journal · 2025Article
- Diversity of DNA viruses in the atmosphere of sub-Antarctic South Georgia.Frontiers in microbiology · 2025Article
- Survival strategies of planktonic organisms in alpine lakes and beyond: Baldi Memorial Award Lecture presented at the 37th Congress of the International Society of Limnology.Inland waters : journal of the International Society of Limnology · 2025Article
- Profiles and natural drivers of antibiotic resistome in multiple environmental media in penguin-colonized area in Antarctica.Fundamental research · 2025Article
- Article
- Seasonal dynamics and diversity of Antarctic marine viruses reveal a novel viral seascape.Nature communications · 2024Article
- Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists.Nature communications · 2024Article
- The polinton-like supergroup of viruses: evolution, molecular biology, and taxonomy.Microbiology and molecular biology reviews : MMBR · 2024Review
- Virophages, Satellite Viruses, Virophage Replication and Its Effects and Virophage Defence Mechanisms for Giant Virus Hosts and Giant Virus Defence Systems against Virophages.International journal of molecular sciences · 2024Review
90 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses are abundant ubiquitous members of microbial communities and in the marine environment affect population structure and nutrient cycling by infecting and lysing primary producers. Antarctic lakes are microbially dominated ecosystems supporting truncated food webs in which viruses exert a major influence on the microbial loop. Here we report the discovery of a virophage (relative of the recently described Sputnik virophage) that preys on phycodnaviruses that infect prasinophytes (phototrophic algae). By performing metaproteogenomic analysis on samples from Organic Lake, a hypersaline meromictic lake in Antarctica, complete virophage and near-complete phycodnavirus genomes were obtained. By introducing the virophage as an additional predator of a predator-prey dynamic model we determined that the virophage stimulates secondary production through the microbial loop by reducing overall mortality of the host and increasing the frequency of blooms during polar summer light periods. Virophages remained abundant in the lake 2 y later and were represented by populations with a high level of major capsid protein sequence variation (25-100% identity). Virophage signatures were also found in neighboring Ace Lake (in abundance) and in two tropical lakes (hypersaline and fresh), an estuary, and an ocean upwelling site. These findings indicate that virophages regulate host-virus interactions, influence overall carbon flux in Organic Lake, and play previously unrecognized roles in diverse aquatic ecosystems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.