ArticleProceedings of the National Academy of Sciences of the United States of America2011
Aquaporin water channel AgAQP1 in the malaria vector mosquito Anopheles gambiae during blood feeding and humidity adaptation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 95 citations in OpenAlex.
- Surviving Alpine Winters Without Dehydration: Physiological and Transcriptomic Insights into the Freeze Avoidance ofInsects · 2026Article
- Effect of prolonged dehydration stress on the vector competence ofbioRxiv : the preprint server for biology · 2025Article
- A global mathematical model of climatic suitability for Plasmodium falciparum malaria.Malaria journal · 2024Article
- Protein localization of aquaporins in the adult female disease vector mosquito,Frontiers in insect science · 2024Article
- Dehydration stress and Mayaro virus vector competence inJournal of virology · 2023Article
- Humidity - The overlooked variable in the thermal biology of mosquito-borne disease.Ecology letters · 2023Article
- Dehydration Alters Transcript Levels in the Mosquito Midgut, Likely Facilitating Rapid Rehydration following a Bloodmeal.Insects · 2023Article
- Article
- Molecular Characterization and Gene Expression Analysis of Aquaporin inFrontiers in physiology · 2022Article
- Double-Strand RNA (dsRNA) Delivery Methods in Insects: Diaphorina citri.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021Review
- Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis.GigaScience · 2021Article
- Specialized stellate cells offer a privileged route for rapid water flux inProceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Article
- Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes.BMC infectious diseases · 2019Article
- A Novel Aquaporin 12-like Protein fromGenes · 2019Article
- An aquaporin mediates cell shape change required for cellular immunity in the beet armyworm, Spodoptera exigua.Scientific reports · 2019Article
- Identification, Expression Patterns and RNA Interference of Aquaporins inFrontiers in physiology · 2019Article
- Dehydration prompts increased activity and blood feeding by mosquitoes.Scientific reports · 2018Article
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5 authors at 1 institution in 1 country.
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Abstract
Altered patterns of malaria endemicity reflect, in part, changes in feeding behavior and climate adaptation of mosquito vectors. Aquaporin (AQP) water channels are found throughout nature and confer high-capacity water flow through cell membranes. The genome of the major malaria vector mosquito Anopheles gambiae contains at least seven putative AQP sequences. Anticipating that transmembrane water movements are important during the life cycle of A. gambiae, we identified and characterized the A. gambiae aquaporin 1 (AgAQP1) protein that is homologous to AQPs known in humans, Drosophila, and sap-sucking insects. When expressed in Xenopus laevis oocytes, AgAQP1 transports water but not glycerol. Similar to mammalian AQPs, water permeation of AgAQP1 is inhibited by HgCl(2) and tetraethylammonium, with Tyr185 conferring tetraethylammonium sensitivity. AgAQP1 is more highly expressed in adult female A. gambiae mosquitoes than in males. Expression is high in gut, ovaries, and Malpighian tubules where immunofluorescence microscopy reveals that AgAQP1 resides in stellate cells but not principal cells. AgAQP1 expression is up-regulated in fat body and ovary by blood feeding but not by sugar feeding, and it is reduced by exposure to a dehydrating environment (42% relative humidity). RNA interference reduces AgAQP1 mRNA and protein levels. In a desiccating environment (<20% relative humidity), mosquitoes with reduced AgAQP1 protein survive significantly longer than controls. These studies support a role for AgAQP1 in water homeostasis during blood feeding and humidity adaptation of A. gambiae, a major mosquito vector of human malaria in sub-Saharan Africa.
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