ArticleProceedings of the National Academy of Sciences of the United States of America2011
Macromolecular structural dynamics visualized by pulsed dose control in 4D electron microscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Direct Imaging of the Crystalline Domains and Their Orientation in the PS-Macromolecules · 2024Article
- Porous and Meltable Metal-Organic Polyhedra for the Generation and Shaping of Porous Mixed-Matrix Composites.Journal of the American Chemical Society · 2024Article
- Precision-controlled ultrafast electron microscope platforms. A case study: Multiple-order coherent phonon dynamics in 1T-TaSeStructural dynamics (Melville, N.Y.) · 2024Article
- Photodiode-based time zero determination for ultrafast electron microscopy.Structural dynamics (Melville, N.Y.) · 2023Article
- Mitigating Damage to Hybrid Perovskites Using Pulsed-Beam TEM.ACS omega · 2020Article
- Direct imaging of plasma waves using ultrafast electron microscopy.Structural dynamics (Melville, N.Y.) · 2020Article
- Dynamics and control of gold-encapped gallium arsenide nanowires imaged by 4D electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Ultrafast electron microscopy integrated with a direct electron detection camera.Structural dynamics (Melville, N.Y.) · 2017Article
- Dominance of misfolded intermediates in the dynamics of α-helix folding.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Macromolecular conformation dynamics, which span a wide range of time scales, are fundamental to the understanding of properties and functions of their structures. Here, we report direct imaging of structural dynamics of helical macromolecules over the time scales of conformational dynamics (ns to subsecond) by means of four-dimensional (4D) electron microscopy in the single-pulse and stroboscopic modes. With temporally controlled electron dosage, both diffraction and real-space images are obtained without irreversible radiation damage. In this way, the order-disorder transition is revealed for the organic chain polymer. Through a series of equilibrium-temperature and temperature-jump dependencies, it is shown that the metastable structures and entropy of conformations can be mapped in the nonequilibrium region of a "funnel-like" free-energy landscape. The T-jump is introduced through a substrate (a "hot plate" type arrangement) because only the substrate is made to absorb the pulsed energy. These results illustrate the promise of ultrafast 4D imaging for other applications in the study of polymer physics as well as in the visualization of biological phenomena.
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