ArticleJournal of lipid research2011
The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
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- Identification of a Chromosome 1 Substitution Line B6-Chr1BLD as a Novel Hyperlipidemia ModelMetabolites · 2022Article
- WWOX and metabolic regulation in normal and pathological conditions.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Integrative Analyses RevealCells · 2021Article
- WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders.International journal of molecular sciences · 2020Review
- Candidate Regulators of Dyslipidemia in Chromosome 1 Substitution Lines Using Liver Co-Expression Profiling Analysis.Frontiers in genetics · 2019Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- N-acetylgalactosaminyltransferases in cancer.Oncotarget · 2016Review
- The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder.Frontiers in behavioral neuroscience · 2015Article
- Review
- A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.Lipids in health and disease · 2014Article
- Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.BMC genomics · 2014Article
- WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Biochimica et biophysica acta · 2014Review
- The WWOX gene modulates high-density lipoprotein and lipid metabolism.Circulation. Cardiovascular genetics · 2014Article
- Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection.PloS one · 2014Article
- Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice.G3 (Bethesda, Md.) · 2013Article
- A major X-linked locus affects kidney function in mice.Molecular genetics and genomics : MGG · 2012Article
- Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.Physiological genomics · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by human studies. We used the mouse quantitative trait loci (QTL) map to interpret results from a GWA study for genes associated with plasma HDL cholesterol levels. We first positioned single nucleotide polymorphisms (SNPs) from a human GWA study on the genomic map for mouse HDL QTL. We then used mouse bioinformatics, sequencing, and expression studies to add evidence for one well-known HDL gene (Abca1) and three newly identified genes (Galnt2, Wwox, and Cdh13), thus supporting the results of the human study. For GWA peaks that occur in human haplotype blocks with multiple genes, we examined the homologous regions in the mouse to prioritize the genes using expression, sequencing, and bioinformatics from the mouse model, showing that some genes were unlikely candidates and adding evidence for candidate genes Mvk and Mmab in one haplotype block and Fads1 and Fads2 in the second haplotype block. Our study highlights the value of mouse genetics for evaluating genes found in human GWA studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.