ArticleJournal of cell science2011
A central multifunctional role of integrin-linked kinase at muscle attachment sites.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- ILK binding to β1 integrin is indirect and mediated by kindlin-2.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrin-linked kinase (ILK) in hematologic malignancies: Bridging molecular mechanisms to therapeutic innovation.BioImpacts : BI · 2026Review
- Integrin restriction by miR-34 protects germline progenitors from cell death during aging.Aging cell · 2024Article
- Interommatidial cells build a tensile collagen network during Drosophila retinal morphogenesis.Current biology : CB · 2023Article
- Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests.Nucleic acids research · 2022Article
- Epithelial morphogenesis in theFrontiers in cell and developmental biology · 2022Article
- GTW inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer via ILK/AKT/GSK3β/Slug Signalling Pathway.Journal of Cancer · 2021Article
- Article
- An alternative mode of epithelial polarity in the Drosophila midgut.PLoS biology · 2018Article
- Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment ineLife · 2018Article
- Article
- Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes.Journal of cell science · 2016Article
- Alternative mechanisms for talin to mediate integrin function.Current biology : CB · 2015Article
- Rsu1 contributes to cell adhesion and spreading in MCF10A cells via effects on P38 map kinase signaling.Cell adhesion & migration · 2015Article
- A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.Aging cell · 2014Article
- Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms.Journal of cell communication and signaling · 2013Article
- Dynamic regulation of the structure and functions of integrin adhesions.Developmental cell · 2013Review
- ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.Current opinion in cell biology · 2012Review
- Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development.Current opinion in cell biology · 2012Review
- A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.Journal of cell science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Integrin-linked kinase (ILK) is an essential component of a multiprotein complex that links actin to the plasma membrane. Here, we have used a genetic approach to examine the molecular interactions that are essential for the assembly of this ILK-containing complex at Drosophila muscle attachment sites (MASs). We show that, downstream of integrins, talin plays a decisive role in the recruitment of three proteins: ILK, PINCH and paxillin. The accumulation of ILK at MASs appears to follow an amplification mechanism, suggesting that numerous binding sites are generated by minimal levels of the upstream integrin and talin effectors. This property suggests that ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion. We found that PINCH stability, and its subcellular localization at MASs, depends upon ILK function, but that ILK stability and localization is not dependent upon PINCH. An in vivo structure-function analysis of ILK demonstrated that each ILK domain has sufficient information for its independent recruitment at embryonic MASs, whereas at later developmental stages only the kinase domain was effectively recruited. Our data strengthen the view that the ILK complex is assembled sequentially at sites of integrin adhesion by employing multiple molecular interactions, which collectively stabilize the integrin-actin link.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.