Evidence map›Paper›PMID 21444359›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012

Dynapenia and aging: an update.

Todd M Manini, Brian C Clark

3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 376 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 15 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05795348 nacompletednot on this mapstarted 2023, after this paper: background citation

ForceLoss: Part II - Osteoarthritic Patients. Development and Validation of Methods to Generate Personalised Models for the Differential Diagnosis of the Loss of Muscle Force

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2023 to 2024Enrolled20ConditionsOsteoarthritis, KneeArmsPersonalised Musculoskeletal Modeling
NCT06621875 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effect Of The Presence Of Dynapenia On Posture, Spine Muscle Elasticity, Strength And Endurance In Young Adults

TypeobservationalSponsorAynur AyazzadeRan2024 to 2025Enrolled40ConditionsDynapenia, Muscle Weakness, Sarcopenia
NCT07253714 nacompletednot on this mapstarted 2024, after this paper: background citation

The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes

TypeinterventionalSponsorAtılım UniversityRan2024 to 2024Enrolled31ConditionsSarcopenia in ElderlyArmsClassic exercises, Proprioceptive exercise training
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 15 syntheses or guidelines pooled it, 847 citations in OpenAlex.

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  3. Skeletal muscle alterations in Marfan syndrome: a systematic review.Journal of muscle research and cell motility · 2025
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  15. The Effect of Muscular Strength on Depression Symptoms in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
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  20. Ischemic Preconditioning Improves Handgrip Strength and Functional Capacity in Active Elderly Women.International journal of environmental research and public health · 2022
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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Todd M ManiniInstitute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. tmanini@aging.ufl.edu
Brian C Clark
Institute on Aging · USOhio University · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Intracortical Mechanisms of Muscle WeaknessR15HD065552 · NICHD · OHIO UNIVERSITY ATHENS · PI CLARK, BRIAN C · 2010 to 2011
$620k
Task Specific Exercise for the Clinically DisabledR21AG031974 · NIA · UNIVERSITY OF FLORIDA · PI MANINI, TODD · 2009 to 2010
$328k
NCATS NIH HHS UL1 TR000064NIA NIH HHS P30 AG028740NIA NIH HHS P30AG028740NIA NIH HHS R21 AG031974NIA NIH HHS R21AG031974NICHD NIH HHS R15 HD065552NICHD NIH HHS R15HD065552
6 · The paper itself

Abstract

In 2008, we published an article arguing that the age-related loss of muscle strength is only partially explained by the reduction in muscle mass and that other physiologic factors explain muscle weakness in older adults (Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829-834). Accordingly, we proposed that these events (strength and mass loss) be defined independently, leaving the term "sarcopenia" to be used in its original context to describe the age-related loss of muscle mass. We subsequently coined the term "dynapenia" to describe the age-related loss of muscle strength and power. This article will give an update on both the biological and clinical literature on dynapenia-serving to best synthesize this translational topic. Additionally, we propose a working decision algorithm for defining dynapenia. This algorithm is specific to screening for and defining dynapenia using age, presence or absence of risk factors, a grip strength screening, and if warranted a test for knee extension strength. A definition for a single risk factor such as dynapenia will provide information in building a risk profile for the complex etiology of physical disability. As such, this approach mimics the development of risk profiles for cardiovascular disease that include such factors as hypercholesterolemia, hypertension, hyperglycemia, etc. Because of a lack of data, the working decision algorithm remains to be fully developed and evaluated. However, these efforts are expected to provide a specific understanding of the role that dynapenia plays in the loss of physical function and increased risk for disability among older adults.

Indexed as

AgedAged, 80 and overAgingAlgorithmsAnimalsFemaleGeriatric AssessmentHand StrengthHumansKneeMaleMuscle, SkeletalMuscle StrengthMuscle WeaknessPersons with DisabilitiesRats

Identifiers

PMID21444359
PMCPMC3260480
OpenAlexW2143056100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.