ArticleGenome biology and evolution2011
Sequence evidence for the presence of two tetrapyrrole pathways in Euglena gracilis.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 37 citations in OpenAlex.
- Localization of heme biosynthesis in the diatomFrontiers in plant science · 2025Article
- Heterotrophic euglenid Rhabdomonas costata resembles its phototrophic relatives in many aspects of molecular and cell biology.Scientific reports · 2021Article
- Using Diatom and Apicomplexan Models to Study the Heme Pathway ofInternational journal of molecular sciences · 2021Article
- Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs.Biology · 2021Article
- The Cryptic Plastid ofmSphere · 2020Article
- Peculiar features of the plastids of the colourless alga Euglena longa and photosynthetic euglenophytes unveiled by transcriptome analyses.Scientific reports · 2018Article
- Systematic bacterialization of yeast genes identifies a near-universally swappable pathway.eLife · 2017Article
- An intact plastid genome is essential for the survival of colorless Euglena longa but not Euglena gracilis.Current genetics · 2017Article
- Heme pathway evolution in kinetoplastid protists.BMC evolutionary biology · 2016Article
- Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement.PloS one · 2016Article
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- Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode.PloS one · 2013Article
- Make it, take it, or leave it: heme metabolism of parasites.PLoS pathogens · 2013Article
- Euglena gracilis and Trypanosomatids possess common patterns in predicted mitochondrial targeting presequences.Journal of molecular evolution · 2012Article
- Tetrapyrrole synthesis of photosynthetic chromerids is likely homologous to the unusual pathway of apicomplexan parasites.The Plant cell · 2011Article
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2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Genes encoding enzymes of the tetrapyrrole biosynthetic pathway were searched within Euglena gracilis EST databases and 454 genome reads and their 5' end regions were sequenced when not available. Phylogenetic analyses and protein localization predictions support the hypothesis concerning the presence of two separated tetrapyrrole pathways in E. gracilis. One of these pathways resembles the heme synthesis in primarily heterotrophic eukaryotes and was presumably present in the host cell prior to secondary endosymbiosis with a green alga. The second pathway is similar to the plastid-localized tetrapyrrole syntheses in plants and photosynthetic algae. It appears to be localized to the secondary plastid, presumably derived from an algal endosymbiont and probably serves only for the production of plastidial heme and chlorophyll. Thus, E. gracilis represents an evolutionary intermediate in a metabolic transformation of a primary heterotroph to a photoautotroph through secondary endosymbiosis. We propose here that the tetrapyrrole pathway serves as a highly informative marker for the evolution of plastids and plays a crucial role in the loss of plastids.
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