Evidence map›Paper›PMID 21444220›Full record

ArticleJournal of the American College of Surgeons2011

Cost-effective treatment of patients with symptomatic cholelithiasis and possible common bile duct stones.

Lisa M Brown, Stanley J Rogers, John P Cello, Karen J Brasel, John M Inadomi

Abstract read
In one paragraph

Article in Journal of the American College of Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Meta-analysis of one- vs. two-stage laparoscopic/endoscopic management of common bile duct stones.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012
    Pooled it
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  14. Scoring System for the Management of Acute Gallstone Pancreatitis: Cost Analysis of a Prospective Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
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  17. A novel therapeutic effect of statins on nephrogenic diabetes insipidus.Journal of cellular and molecular medicine · 2015
    Review
  18. MRCP is not a cost-effective strategy in the management of silent common bile duct stones.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lisa M BrownDepartment of Surgery, University of California, San Francisco, CA, USA. Lisa.Brown@ucsfmedctr.org
Stanley J Rogers
John P Cello
Karen J Brasel
John M Inadomi
University of California, San Francisco · USMedical College of Wisconsin · USSan Francisco General Hospital · USUniversity of Washington · US

Funding

TRAUMA AND BURNST32GM008258 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOUNG, DAVID M · 1988 to 2012
$2.3M
Improving Gastrointestinal Disease Outcomes in Vulnerable PopulationsK24DK080941 · NIDDK · UNIVERSITY OF WASHINGTON · PI INADOMI, JOHN MATTHEW · 2008 to 2019
$1.8M
NHLBI NIH HHS L30 HL094248NIDDK NIH HHS K24 DK080941NIGMS NIH HHS T32 GM008258NIGMS NIH HHS T32 GM008258-21
6 · The paper itself

Abstract

backgroundClinicians must choose a treatment strategy for patients with symptomatic cholelithiasis without knowing whether common bile duct (CBD) stones are present. The purpose of this study was to determine the most cost-effective treatment strategy for patients with symptomatic cholelithiasis and possible CBD stones. STUDY

designOur decision model included 5 treatment strategies: laparoscopic cholecystectomy (LC) alone followed by expectant management; preoperative endoscopic retrograde cholangiopancreatography (ERCP) followed by LC; LC with intraoperative cholangiography (IOC) ± common bile duct exploration (CBDE); LC followed by postoperative ERCP; and LC with IOC ± postoperative ERCP. The rates of successful completion of diagnostic testing and therapeutic intervention, test characteristics (sensitivity and specificity), morbidity, and mortality for all procedures are from current literature. Hospitalization costs and lengths of stay are from the 2006 National Centers for Medicare and Medicaid Services data. The probability of CBD stones was varied from 0% to 100% and the most cost-effective strategy was determined at each probability.

resultsAcross the CBD stone probability range of 4% to 100%, LC with IOC ± ERCP was the most cost-effective. If the probability was 0%, LC alone was the most cost-effective. Our model was sensitive to 1 health input: specificity of IOC, and 3 costs: cost of hospitalization for LC with CBDE, cost of hospitalization for LC without CBDE, and cost of LC with IOC.

conclusionsThe most cost-effective treatment strategy for the majority of patients with symptomatic cholelithiasis is LC with routine IOC. If stones are detected, CBDE should be forgone and the patient referred for ERCP.

Indexed as

Decision Support TechniquesAdultAgedCholangiographyCholangiopancreatography, Endoscopic RetrogradeCholangiopancreatography, Magnetic ResonanceCholecystectomy, LaparoscopicCholelithiasisCost-Benefit AnalysisCost ControlEndosonographyFemaleGallstonesHumansIntraoperative PeriodLength of Stay

Identifiers

PMID21444220
PMCPMC3163150
OpenAlexW2131417827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.