Evidence map›Paper›PMID 21443893›Full record

ArticlePhysiology & behavior2011

A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques.

Michael A Taffe

Abstract readComparative Study
In one paragraph

Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Michael A TaffeCommittee on Neurobiology of Addictive Disorders, SP30-2400, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, USA. mtaffe@scripps.edu

Funding

TRANSLATIONAL CTR ON THE CLINICAL NEUROBIOL OF CANNABIS ADDICTIONP20DA024194 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI MASON, BARBARA J · 2007 to 2010
$3.8M
BEHAVIORAL TOXICITY OF MDMA IN RHESUS MONKEYSR01DA018418 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI TAFFE, MICHAEL A. · 2005 to 2009
$2.0M
NIDA NIH HHS DA018418NIDA NIH HHS DA024194NIDA NIH HHS P20 DA024194NIDA NIH HHS R01 DA018418
6 · The paper itself

Abstract

rationaleThe remote measurement of body temperature with radiotelemetry provides a minimally invasive and robust method for larger experimental animals such as Old World monkeys. Existing literature encompasses data using intraperitoneal (IP) and subcutaneous (SC) implantation locations which may affect inferences about body temperature.

methodsThe body temperatures of four adult male rhesus monkeys were monitored with radiotelemetry devices implanted both IP and SC in each subject. Animals were recorded at 5 min intervals for 5 months with the two transmitters being used in sequence on a weekly basis. Additional challenge with d-methamphetamine (0.32 mg/kg; i.m.) was conducted to compare the magnitude of the hyperthermic response measured IP and SC.

resultsNormal daily temperatures differed by about 0.5-0.8°C across implant locations with IP temperature consistently higher. The difference was consistent across the circadian cycle and when compared 1, 3 or 5 months after surgical implantation. The magnitude of the hyperthermia response to methamphetamine was about 0.75°C when measured with either IP or SC implants.

conclusionsThe study shows that data derived from the two major implantation locations used in existing literature are likely to be comparable.

Indexed as

AnimalsBody TemperatureCircadian RhythmFeverImplants, ExperimentalMacaca mulattaMaleMethamphetamineTelemetryTime FactorsMethamphetamine

Identifiers

PMID21443893
PMCPMC3107936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.