Trial reportCanadian journal of surgery. Journal canadien de chirurgie2011
Randomized controlled trial to investigate the impact of anticoagulation on the incidence of splenic or portal vein thrombosis after laparoscopic splenectomy.
Trial report in Canadian journal of surgery. Journal canadien de chirurgie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Low-molecular weight heparin prevents portal vein system thrombosis after splenectomy: a systematic review and meta-analysis.ANZ journal of surgery · 2020Pooled it
- Laparoscopic Splenectomy for Benign Hematological Disorders in Adults: A Systematic Review.In vivo (Athens, Greece)Pooled it
- Porto-spleno-mesenteric venous thrombosis after elective splenectomy: a retrospective cohort study.Frontiers in immunology · 2023Article
- Effects of early antiplatelet therapy after splenectomy with gastro-oesophageal devascularization.ANZ journal of surgery · 2018Article
- Hassab's operation for Joubert syndrome with congenital hepatic fibrosis: A case report.International journal of surgery case reports · 2017Article
- Early prophylactic anticoagulation for portal vein system thrombosis after splenectomy: A systematic review and meta-analysis.Biomedical reports · 2016Article
- Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model.Oxidative medicine and cellular longevity · 2016Article
- A comparative study of two anti-coagulation plans on the prevention of PVST after laparoscopic splenectomy and esophagogastric devascularization.Journal of thrombosis and thrombolysis · 2015Article
- Predictive model of portal venous system thrombosis in cirrhotic portal hypertensive patients after splenectomy.International journal of clinical and experimental medicine · 2015Article
- Pharmacologic prophylaxis of portal venous system thrombosis after splenectomy: a meta-analysis.Gastroenterology research and practice · 2014Review
- Portal vein thrombosis after laparoscopic splenectomy during childhood.Journal of thrombosis and thrombolysis · 2014Article
- Laparoscopic splenectomy: a single center experience. Unusual cases and expanded inclusion criteria for laparoscopic approach.Updates in surgery · 2013Article
- Anticoagulation therapy prevents portal-splenic vein thrombosis after splenectomy with gastroesophageal devascularization.World journal of gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSplenic and portal vein thrombosis (SPVT) is a potentially life-threatening complication of splenectomy. There is a paucity of studies examining the role of prophylactic pre- and postoperative anticoagulation in the prevention of this complication. We designed a prospective randomized controlled trial (RCT) to more rigorously address the impact of prophylactic anticoagulation on the incidence of asymptomatic or symptomatic SPVT, detected on Doppler ultrasound, after laparoscopic splenectomy.
methodsThis 2-centre, phase II, prospective, open-label, parallel-assignment RCT compared no postoperative anticoagulation to a regimen of 40 mg of enoxaparin subcutaneously once daily for 21 days. All patients underwent Doppler ultrasonography of the splenoportal system preoperatively and again 14-28 days after surgery to screen for nonocclusive or occlusive thrombosis.
resultsFrom November 2006 to November 2008, 35 patients were enrolled in the RCT. Four patients withdrew, 1 required conversion to an open procedure and 1 died at 3 months (the cause of death was not related to the study). Of the 29 patients remaining, 15 were randomly assigned to the anticoagulation group and 14 to the nonanticoagulation group. One (3.4%) patient in the treatment group experienced portal thrombosis. Rates of postoperative bleeding were similar in both groups.
conclusionThis RCT of anticoagulation found a low overall risk of SPVT after laparoscopic splenectomy; however, this is an underpowered study, and further multicentred clinical trials are needed.
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