Evidence map›Paper›PMID 21443677›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011

Estimating the potential pool of HIV-infected deceased organ donors in the United States.

B J Boyarsky, E C Hall, A L Singer, R A Montgomery, K A Gebo, D L Segev

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 119 citations in OpenAlex.

  1. Review
  2. Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational
  3. Potential pool of cardiothoracic organs from donors with HIV.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  4. Review
  5. Article
  6. Safety of Kidney Transplantation from Donors with HIV.The New England journal of medicine · 2024
    Observational
  7. Article
  8. Review
  9. Efficacy of hope: Analysis of organ quality and availability among deceased HIV-positive donors.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  10. Article
  11. National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  12. HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  13. Review
  14. Article
  15. A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

B J BoyarskyDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
E C Hall
A L Singer
R A Montgomery
K A Gebo
D L Segev
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Quantifying risk from and appropriate recipients for infectious-risk kidneysR21DK089456 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2010 to 2011
$442k
NIAID NIH HHS K24 AI144954NIDDK NIH HHS R21 DK089456NIDDK NIH HHS R21DK089456
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) is no longer a contraindication to transplantation. For HIV-infected patients, HIV-infected deceased donors (HIVDD) could attenuate the organ shortage and waitlist mortality. However, this practice would violate United States federal law. The goal of this study was to estimate the potential impact of legalizing transplantation of HIV-infected organs by quantifying the potential pool of HIVDD. Using Nationwide Inpatient Sample (NIS) data, HIV-infected deaths compatible with donation were enumerated. Using HIV Research Network (HIVRN) data, CD4 count, plasma HIV-1 RNA level, AIDS-defining illnesses and causes of death were examined in potential HIVDD. Using UNOS data, evaluated donors who later demonstrated unanticipated HIV infections were studied. From NIS, a yearly average of 534 (range: 481-652) potential HIVDD were identified, with 63 (range: 39-90) kidney-only, 221 (range: 182-255) liver-only and 250 (range: 182-342) multiorgan donors. From HIVRN, a yearly average of 494 (range: 441-533) potential HIVDD were identified. Additionally, a yearly average of 20 (range: 11-34) donors with unanticipated HIV infection were identified from UNOS. Deceased HIV-infected patients represent a potential of approximately 500-600 donors per year for HIV-infected transplant candidates. In the current era of HIV management, a legal ban on the use of these organs seems unwarranted and likely harmful.

Indexed as

Tissue DonorsCD4 Lymphocyte CountHIV InfectionsHumansUnited StatesViral Load

Identifiers

PMID21443677
PMCPMC3110583
OpenAlexW1500273937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.