ArticleBipolar disorders2011
Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder.
Article in Bipolar disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Review
- Individual prediction of symptomatic converters in youth offspring of bipolar parents using proton magnetic resonance spectroscopy.European child & adolescent psychiatry · 2021Article
- Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.Brain imaging and behavior · 2018Article
- Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.Bipolar disorders · 2018Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Consensus Paper: Cerebellum and Emotion.Cerebellum (London, England) · 2017Article
- A review of MR spectroscopy studies of pediatric bipolar disorder.AJNR. American journal of neuroradiology · 2014Review
- Prospective neurochemical characterization of child offspring of parents with bipolar disorder.Psychiatry research · 2013Article
- Posterior cerebellar vermal deficits in bipolar disorder.Journal of affective disorders · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWe aimed to compare concentrations of N-acetyl aspartate, myo-inositol, and other neurometabolites in the cerebellar vermis of offspring at risk for bipolar disorder (BD) and healthy controls to examine whether changes in these neuronal metabolite concentrations occur in at-risk offspring prior to the onset of mania.
methodsA total of 22 children and adolescents aged 9-17 years with a familial risk for bipolar I or II disorder [at-risk offspring with non-bipolar I disorder mood symptoms (AR)], and 25 healthy controls (HC) were examined using proton magnetic resonance spectroscopy at 3T to study metabolite concentrations in an 8-cc voxel in the cerebellar vermis.
resultsDecreased myo-inositol and choline concentrations in the vermis were seen in the AR group compared to HC (p<0.01).
conclusionsDecreased cellular metabolism and interference with second messenger pathways may be present in the cerebellar vermis in youth at risk for BD as evident by decreased myo-inositol and choline concentrations in this region. These results may be limited by a cross-sectional design, co-occurring diagnoses, and medication exposure. Longitudinal studies are necessary to determine whether early neurochemical changes can predict the development of mania. Improved methods for identifying children with certain neurochemical vulnerabilities may inform preventive and early intervention strategies prior to the onset of mania.
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Registered trials
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