Evidence map›Paper›PMID 21443339›Full record

ArticleNeuropsychology2011

Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia.

Jamie Reilly, Jonathan E Peelle, Sharon M Antonucci, Murray Grossman

Open access · greenAbstract read
In one paragraph

Article in Neuropsychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 86 citations in OpenAlex.

  1. Trial
  2. Focal-DenseNet: A Risk Assessment Framework for Alzheimer's Disease in Heterogeneous MRI Data.Interdisciplinary sciences, computational life sciences · 2026
    Article
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  6. Abstract word dropout and cross-speaker misalignment of word concreteness are features of conversation in aging.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
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  19. Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jamie ReillyDepartment of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL 32610, USA. jjreilly@phhp.ufl.edu
Jonathan E Peelle
Sharon M Antonucci
Murray Grossman
California University of Pennsylvania · USNew York University · USUniversity of Florida · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Neural Basis of Generalized QuantifiersR01NS044266 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 2004 to 2014
$6.8M
CONCEPTUAL PROCESSING IN ALZHEIMERS DISEASER01AG015116 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 1998 to 2010
$4.3M
Structure of Semantic Memory and its Measurement in Dementia and AphasiaK23DC010197 · NIDCD · UNIVERSITY OF FLORIDA · PI REILLY, JAMES JOSEPH · 2009 to 2013
$858k
Medical Research CouncilNIA NIH HHS AG15116NIA NIH HHS AG17586NIA NIH HHS P01 AG017586NIA NIH HHS R01 AG015116NIDCD NIH HHS K23 DC010197NINDS NIH HHS NS44266NINDS NIH HHS NS53488NINDS NIH HHS P50 NS053488NINDS NIH HHS R01 NS044266
6 · The paper itself

Abstract

objectiveMany neurologically constrained models of semantic memory have been informed by two primary temporal lobe pathologies: Alzheimer's disease (AD) and Semantic Dementia (SD). However, controversy persists regarding the nature of the semantic impairment associated with these patient populations. Some argue that AD presents as a disconnection syndrome in which linguistic impairment reflects difficulties in lexical or perceptual means of semantic access. In contrast, there is a wider consensus that SD reflects loss of core knowledge that underlies word and object meaning. Object naming provides a window into the integrity of semantic knowledge in these two populations.

methodWe examined naming accuracy, errors and the correlation of naming ability with neuropsychological measures (semantic ability, executive functioning, and working memory) in a large sample of patients with AD (n = 36) and SD (n = 21).

resultsNaming ability and naming errors differed between groups, as did neuropsychological predictors of naming ability. Despite a similar extent of baseline cognitive impairment, SD patients were more anomic than AD patients.

conclusionsThese results add to a growing body of literature supporting a dual impairment to semantic content and active semantic processing in AD, and confirm the fundamental deficit in semantic content in SD. We interpret these findings as supporting of a model of semantic memory premised upon dynamic interactivity between the process and content of conceptual knowledge.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAnalysis of VarianceAnomiaFemaleFrontotemporal Lobar DegenerationHumansMaleMemory DisordersNamesNeuropsychological TestsSemanticsStatistics as Topic

Identifiers

PMID21443339
PMCPMC3125450
OpenAlexW2128913428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.