ReviewPflugers Archiv : European journal of physiology2011
Klotho: a novel regulator of calcium and phosphorus homeostasis.
Review in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 77 citations in OpenAlex.
- Distinct effects of aging and klotho deletion on the choroid plexus.GeroScience · 2026Article
- Calcium Nitrate Supplementation Improves Meat Quality in Hu Sheep via Microbial and Transcriptomic Regulation.Animals : an open access journal from MDPI · 2026Article
- The Preventive Impact of Chokeberry (Nutrients · 2025Article
- Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007-2016.PloS one · 2024Article
- Effects of Multiwall Carbon Nanotubes on Premature Kidney Aging: Biochemical and Histological Analysis.Toxics · 2023Article
- Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.Frontiers in neuroscience · 2023Article
- The Interrelated Multifactorial Actions of Cortisol and Klotho: Potential Implications in the Pathogenesis of Parkinson's Disease.Brain sciences · 2022Review
- Soluble klotho as an effective biomarker to characterize inflammatory states.Annals of medicine · 2022Article
- Circulating α-klotho regulates metabolism via distinct central and peripheral mechanisms.Metabolism: clinical and experimental · 2021Review
- In search of alternatively spliced alpha-Klotho Kl1 protein in mouse brain.FASEB bioAdvances · 2021Article
- Resveratrol Pretreatment Ameliorates Concanavalin A-Induced Advanced Renal Glomerulosclerosis in Aged Mice through Upregulation of Sirtuin 1-Mediated Klotho Expression.International journal of molecular sciences · 2020Article
- Denosumab-induced severe hypocalcaemia in a patient with vitamin D deficiency.BMJ case reports · 2020Article
- The prognostic value of soluble Klotho in patients with haemodialysis: a systematic review and meta-analysis.Therapeutic advances in chronic disease · 2020Article
- Klotho: An Elephant in Aging Research.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Review
- Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice.Heliyon · 2019Article
- Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression.Frontiers in pharmacology · 2019Article
- Cardiovascular disease in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018 · on this mapReview
- P2XPurinergic signalling · 2018Article
- Role of Bisphosphonates in Vascular calcification and Bone Metabolism: A Clinical Summary.Current cardiology reviews · 2018Review
- Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease.Kidney diseases (Basel, Switzerland) · 2017Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Klotho which was originally identified as an anti-aging protein is emerging as a substance with multiple effects on many systems including mineral homeostasis. In addition to its membrane-bound function as a co-receptor for fibroblast growth factor-23, soluble Klotho exerts effects as a circulating substance in plasma and urine. Novel features of this system include its autocrine-paracrine-endocrine glycan-modifying enzymatic function in the urinary lumen on calcium and phosphate transporters. Klotho induces phosphaturia by inhibiting the proximal tubule Na-coupled phosphate transporter. The action of Klotho is enzymatic in nature which includes alteration of transport activity and the more traditional means of regulation by trafficking. Klotho reduces calciuria by its distal as a sialidase directly on the apical calcium channel. Desialidation of the channel exposes glycan residues that promote binding to galectin-1, resulting in stabilization of residence on the plasma membrane. Through its systematic as well as renal actions, Klotho is emerging as a principal calciophosphoregulatory hormone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.