ArticleEuropean journal of nutrition2012
Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds.
Article in European journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 149 citations in OpenAlex.
- Discovery and molecular insights of a novel pea-derived antioxidant peptide: From quantum chemical insights to oxidative stability of walnut oil.Food chemistry: X · 2026Article
- Extraction of Soybean and Pea Protein Isolates to Evaluate Therapeutic Potential Against Dexamethasone-Induced Osteoporosis: In Vivo andFood science & nutrition · 2026Article
- A Topical Combination of Xyloglucan and Pea Protein Effectively Manages Oral Ulcers In Vivo.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
- Article
- Quantification of Peptides in Food Hydrolysate fromFoods (Basel, Switzerland) · 2025Article
- Quinoa Protein Hydrolysate as Potential Immunomodulators: Effects on Cytokine Production and Macrophage Activation.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- Nutritional, Antibacterial and Thrombolytic Prospects of FreshwaterFood science & nutrition · 2025Article
- Unlocking the Nutraceutical Potential of Legumes and Their By-Products: Paving the Way for the Circular Economy in the Agri-Food Industry.Antioxidants (Basel, Switzerland) · 2024Review
- Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study.Dermatology and therapy · 2023Article
- Bioactivities of Garcinia kola enzymatic hydrolysates at different enzyme-substrate ratios.AMB Express · 2023Article
- RNA-seq analysis reveals an immunomodulatory peptide from highland barley activating RAW264.7 macrophages via TNF/NF-κB signaling pathway.Functional & integrative genomics · 2023Article
- Therapeutic Applications and Effects ofFoods (Basel, Switzerland) · 2023Review
- Topical Application of a Formulation Containing Pea Proteins and Xyloglucan in Adult Patients with Atopic Dermatitis: A Double-blind, Parallel, Randomized, Placebo-controlled, Multicenter Study.The Journal of clinical and aesthetic dermatology · 2023Article
- A Comprehensive Review of Pea (Foods (Basel, Switzerland) · 2023Review
- Potential Role of Bioactive Proteins and Peptides Derived from Legumes towards Metabolic Syndrome.Nutrients · 2022Review
- Bioactive peptides from broccoli stems strongly enhance regenerative keratinocytes by stimulating controlled proliferation.Pharmaceutical biology · 2022Article
- The Inhibitory Effect of Phycocyanin Peptide on Pulmonary FibrosisMarine drugs · 2022Article
- Article
- Alleviating effects of pea peptide on oxidative stress injury induced by lead in PC12 cellsFrontiers in nutrition · 2022Article
- Potential role of resveratrol and its nano-formulation as anti-cancer agent.Exploration of targeted anti-tumor therapy · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEnzymatic protein hydrolysates of yellow pea seed have been shown to possess high anti-oxidant and anti-bacterial activities. The aim of this work was to confirm the anti-oxidant, anti-inflammatory and immunomodulating activities of an enzymatic protein hydrolysate of yellow field pea seeds.
methodsThe anti-oxidant and anti-inflammatory properties of peptides from yellow field pea proteins (Pisum sativum L.) were investigated in LPS/IFN-γ-activated RAW 264.7 NO⁻ macrophages. The immunomodulating potential of pea protein hydrolysate (PPH) was then studied in a murine model.
resultsPea protein hydrolysate, after a 12 h pre-treatment, showed significant inhibition of NO production by activated macrophages up to 20%. Moreover, PPH significantly inhibited their secretion of pro-inflammatory cytokines, TNF-α- and IL-6, up to 35 and 80%, respectively. Oral administration of PPH in mice enhanced the phagocytic activity of their peritoneal macrophages and stimulated the gut mucosa immune response. The number of IgA+ cells was elevated in the small intestine lamina propria, accompanied by an increase in the number of IL-4+, IL-10+ and IFN-γ+ cells. This was correlated to up-regulation of IL-6 secretion by small intestine epithelial cells (IEC), probably responsible for B-cell terminal differentiation to IgA-secreting cells. Moreover, PPH might have increased IL-6 production in IECs via the stimulation of toll-like receptors (TLRs) family, especially TLR2 and TLR4 since either anti-TLR2 or anti-TLR4 was able to completely abolish PPH-induced IL-6 secretion.
conclusionsEnzymatic protein degradation confers anti-oxidant, anti-inflammatory and immunomodulating potentials to pea proteins, and the resulted peptides could be used as an alternative therapy for the prevention of inflammatory-related diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.