ArticleJournal of molecular histology2011
Expressions of CXCR7/ligands may be involved in oral carcinogenesis.
Article in Journal of molecular histology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- MiRNA-related metastasis in oral cancer: moving and shaking.Cancer cell international · 2023Review
- Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway.Frontiers in immunology · 2021Article
- CXCR7, a Prognostic Biomarker in Cervical Squamous Cell Carcinoma, May Be a Screening Index for Treatment Options at Stages IB1 and IIA1.Cancer management and research · 2019Article
- Identification of Potential Candidate Genes of Oral Cancer in Response to Chronic Infection WithFrontiers in oncology · 2019Article
- Oral inflammation promotes oral squamous cell carcinoma invasion.Oncotarget · 2018Article
- Four and a half LIM domains 2 contributes to the development of human tongue squamous cell carcinoma.Journal of molecular histology · 2016Article
- Elevated autocrine chemokine ligand 18 expression promotes oral cancer cell growth and invasion via Akt activation.Oncotarget · 2016Article
- miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7.American journal of translational research · 2016Article
- CXCL12-CXCR4/CXCR7 axis contributes to cell motilities of oral squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- C-X-C motif receptor 7 in gastrointestinal cancer.Oncology letters · 2015Article
- Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.British journal of cancer · 2014Article
- Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.The Journal of biological chemistry · 2013Article
- Expressions of CXCL12/CXCR4 in oral premalignant and malignant lesions.Mediators of inflammation · 2012Article
- Dickkopf (Dkk)-3 and β-catenin expressions increased in the transition from normal oral mucosal to oral squamous cell carcinoma.Journal of molecular histology · 2011Article
- The Role of CXCL11 and its Receptors in Cancer: Prospective but Challenging Clinical Targets.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral carcinogenesis is a multistep process and requires accumulation and interplay of a series of molecular events. Chemokines and their receptors have been suggested to play important roles in the initiation or progression of cancers. Until now, no report focuses on their alterations in premalignant stage of oral squamous cell carcinoma (OSCC). Compared with normal tissues, mRNA levels of 9 chemokines and 3 chemokine receptors including CXCR7 in oral leukoplakia (OLK) were increased more than two folds by microarray analysis. Then, CXCR7 was selected for further confirmation and immunohistochemistry examination during multistage oral carcinogenesis. CXCR7 was expressed in 85% of OLK and 86% of OSCC. However, only 8% (1 of 13 cases) of normal tissue displayed CXCR7 immunostaining. The positive ratios of CXCR7, CXCL12 and CXCL11 in OLK and OSCC tissues respectively, were significantly higher than that in normal epithelia (P < 0.05), although no significant difference was found between OLK and OSCC. Meanwhile, CXCR7 always concomitantly expressed with it ligands in OLK and OSCC tissues. Our results indicated that CXCR7-CXCL12/CXCL11 axis might play important roles in oral carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.