ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
Treatment of pediatric refractory status epilepticus with topiramate.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Efficacy of topiramate as an add-on therapy in patients with refractory status epilepticus: a short systematic review.Revista Brasileira de terapia intensiva · 2021Pooled it
- Pooled it
- Pooled it
- [Paediatric status epilepticus].Revista de neurologia · 2022Review
- Pharmacotherapy for Pediatric Convulsive Status Epilepticus.CNS drugs · 2020Review
- Antiseizure medications in critical care: an update.Current opinion in critical care · 2019Review
- Management of Status Epilepticus in Children.Journal of clinical medicine · 2016Review
- Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy.Frontiers in veterinary science · 2016Article
- Newer antiepileptic drugs: evidence based use.Indian journal of pediatrics · 2014Review
- Management of pediatric status epilepticus.Current treatment options in neurology · 2014Article
- Topiramate as an adjunctive treatment in patients with refractory status epilepticus: an observational cohort study.CNS drugs · 2012Article
- The safety and tolerability of newer antiepileptic drugs in children and adolescents.Journal of central nervous system disease · 2012Article
- Treatment of pediatric status epilepticus.Current treatment options in neurology · 2011Article
- Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
- Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe evaluated a topiramate (TPM) regimen for treating refractory status epilepticus in the largest pediatric series, reported to date.
methodsFourteen patients received TPM via the nasogastric route. Initially, all patients received TPM as a 5 mg/kg loading dose followed by 5 mg/kg/day in two doses as maintenance. Thereafter, patients were divided into three groups based on the response to TPM therapy and seizure cessation time (full responder, partial responder, and nonresponder). Four patients received only thiopental, two received thiopental, and high-dose midazolam, one received thiopental, high-dose midazolam, and propofol, two received only propofol, one received propofol, and high-dose midazolam and four patients were on a high-dose midazolam infusion.
resultsThe median time to seizure cessation was 5.5 h (range 2-48 h). Nine patients were full responders, three were partial responders, and two were nonresponders At follow-up, six patients were weaned successfully from thiopental, two patients from high-dose midazolam and three patients from propofol. Three patients developed mild metabolic acidosis during TPM theraphy.
conclusionsMost of the patients responded to this treatment which was well tolerated. So we recommended its use for terminating refractory status epilepticus in children.
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