Evidence map›Paper›PMID 21442198›Full record

Trial reportBreast cancer research and treatment2011

Women's interest in taking tamoxifen and raloxifene for breast cancer prevention: response to a tailored decision aid.

Angela Fagerlin, Amanda J Dillard, Dylan M Smith, Brian J Zikmund-Fisher, Rosemarie Pitsch, Jennifer B McClure, Sarah Greene, Sharon Hensley Alford, Vijayan Nair, Daniel F Hayes and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Breast cancer research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Pooled it
  5. Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016
    Pooled it
  6. Pooled it
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  13. Article
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  15. Article
  16. Effective communication regarding risk of fracture for individuals at risk of fragility fracture: a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  17. Article
  18. Article
  19. Multimorbidity: Implications and directions for health psychology and behavioral medicine.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Angela FagerlinAnn Arbor VA HSR&D Center for Practice Management and Outcomes Research, Ann Arbor, MI, USA. fagerlin@umich.edu
Amanda J Dillard
Dylan M Smith
Brian J Zikmund-Fisher
Rosemarie Pitsch
Jennifer B McClure
Sarah Greene
Sharon Hensley Alford
Vijayan Nair
Daniel F Hayes
Cheryl Wiese
Peter A Ubel
University of Michigan–Ann Arbor · USDecision Sciences (United States) · USGroup Health Cooperative · USVA Center for Clinical Management Research · USDuke University · USHealth Center · USHenry Ford Health System · US

Funding

Training / Career DevelopmentP50CA101451 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTON, LAFATA J, RESNICOW, KEN A. · 2003 to 2012
$18.2M
NCI NIH HHS P50 CA101451
6 · The paper itself

Abstract

Although tamoxifen can prevent primary breast cancer, few women use it as a preventive measure. A second option, raloxifene, has recently been approved. The objective of the study was to determine women's interest in tamoxifen and raloxifene after reading a decision aid (DA) describing the risks and benefits of each medication. Women with 5-year risk of breast cancer ≥ 1.66 from two large health maintenance organizations were randomized to receive a DA versus usual care. After reading an on-line DA that discussed the risks and benefits of tamoxifen and raloxifene, women completed measures of risk perception, decisional conflict, behavioral intentions, and actual behavior related to tamoxifen and raloxifene. 3 months following the intervention, 8.1% of participants had looked for additional information about breast cancer prevention drugs, and 1.8% had talked to their doctor about tamoxifen and/or raloxifene. The majority, 54.7%, had decided to not take either drug, 0.5% had started raloxifene, and none had started tamoxifen. Participants were not particularly worried about taking tamoxifen or raloxifene and did not perceive significant benefits from taking these drugs. Over 50% did not perceive a change in their risk of getting breast cancer if they took tamoxifen or raloxifene. After reading a DA about tamoxifen and raloxifene, few women were interested in taking either breast cancer prevention drug.

Indexed as

AdultAgedAnticarcinogenic AgentsBreast NeoplasmsDecision MakingFemaleHealth Knowledge, Attitudes, PracticeHumansMiddle AgedPatient Education as TopicRaloxifene HydrochlorideSelective Estrogen Receptor ModulatorsTamoxifenAnticarcinogenic AgentsRaloxifene HydrochlorideSelective Estrogen Receptor ModulatorsTamoxifen

Identifiers

PMID21442198
PMCPMC3742062
OpenAlexW2127107636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.