ArticlePhysical chemistry chemical physics : PCCP2011
Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel.
Article in Physical chemistry chemical physics : PCCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Exploring the anticancer potential of green silver Nanoparticles-Paclitaxel nanocarrier on MCF-7 breast Cancer cells: an in vitro approach.Scientific reports · 2025Article
- Design and Characterization of Carboplatin and Paclitaxel Loaded PCL Filaments for 3D Printed Controlled Release Intrauterine Implants.Pharmaceutics · 2023Article
- Review
- Recent advances in nanocarriers for nutrient delivery.Drug delivery and translational research · 2022Review
- Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine.Bioactive materials · 2021Article
- Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery.Environmental science and pollution research international · 2020Review
- Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles.Acta pharmaceutica Sinica. B · 2019Review
- Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity.Drug design, development and therapy · 2018Article
- Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting.Drug design, development and therapy · 2017Article
- Engineering nanolayered particles for modular drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Spherical and tubule nanocarriers for sustained drug release.Current opinion in pharmacology · 2014Review
- Osteotropic therapy via targeted layer-by-layer nanoparticles.Advanced healthcare materials · 2014Article
- Article
- Article
- Advances in Integrative Nanomedicine for Improving Infectious Disease Treatment in Public Health.European journal of integrative medicine · 2013Article
- Architectural layer-by-layer assembly of drug nanocapsules with PEGylated polyelectrolytes.Soft matter · 2012Article
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6 authors.
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Abstract
Nano-encapsulation of a poorly soluble anticancer drug was demonstrated with a sonication assisted layer-by-layer polyelectrolyte coating (SLbL). We changed the strategy of LbL-encapsulation from making microcapsules with many layers in the walls for encasing highly soluble materials to using a very thin polycation/polyanion coating on low solubility nanoparticles to provide them with good colloidal stability. SLbL encapsulation of paclitaxel resulted in stable 100-200 nm diameter colloids with a high electrical surface ξ-potential (of -45 mV) and drug content in the nanoparticles of 90 wt%. In the top-down approach, nanocolloids were prepared by rupturing a powder of paclitaxel using ultrasonication and simultaneous sequential adsorption of oppositely charged biocompatible polyelectrolytes. In the bottom-up approach paclitaxel was dissolved in organic solvent (ethanol or acetone), and drug nucleation was initiated by the addition of aqueous polyelectrolyte assisted by ultrasonication. Paclitaxel release rates from such nanocapsules were controlled by assembling multilayer shells with variable thicknesses and were in the range of 10-20 h.
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