ReviewNeuroscience bulletin2011
Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases.
Review in Neuroscience bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Systematic review of genome-wide gene expression studies of bipolar disorder.BMC psychiatry · 2013Pooled it
- eQTL analysis: A bridge from genome to mechanism.Genes & diseases · 2026Review
- A twin analysis to estimate genetic and environmental factors contributing to variation in weighted gene co-expression network module eigengenes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence.Alcoholism, clinical and experimental research · 2020Article
- Statistical Methods and Software for Substance Use and Dependence Genetic Research.Current genomics · 2019Review
- Psychiatric Genetics, Epigenetics, and Cellular Models in Coming Years.Journal of psychiatry and brain science · 2019Article
- Genetic analysis of deep phenotyping projects in common disorders.Schizophrenia research · 2018Review
- Common polygenic variation contributes to risk of migraine in the Norfolk Island population.Human genetics · 2015Article
- Molecular mechanisms underlying variations in lung function: a systems genetics analysis.The Lancet. Respiratory medicine · 2015Article
- Article
- Overlap of expression quantitative trait loci (eQTL) in human brain and blood.BMC medical genomics · 2014Article
- The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Systems genetics in "-omics" era: current and future development.Theory in biosciences = Theorie in den Biowissenschaften · 2013Review
- Simultaneous inferences based on empirical Bayes methods and false discovery rates ineQTL data analysis.BMC genomics · 2013Article
- Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain.Genetics · 2012Article
- Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.Biological psychiatry · 2012Article
- Computational tools for discovery and interpretation of expression quantitative trait loci.Pharmacogenomics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Genome-wide association study (GWAS) can be used to identify genes that increase the risk of psychiatric diseases. However, much of the disease heritability is still unexplained, suggesting that there are genes to be discovered. Functional annotation of the genetic variants may increase the power of GWAS to identify disease genes, by providing prior information that can be used in Bayesian analysis or in reducing the number of tests. Expression quantitative trait loci (eQTLs) are genomic loci that regulate gene expression. Genetic mapping of eQTLs can help reveal novel functional effects of thousands of single nucleotide polymorphisms (SNPs). The present review mainly focused on the current knowledge on brain eQTL mapping, and discussed some major methodological issues and their possible solutions. The frequently ignored problems of batch effects, covariates, and multiple testing were emphasized, since they can lead to false positives and false negatives. The future application of eQTL data in GWAS analysis was also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.