ArticleThe Indian journal of medical research2011
Analysis of penicillin-binding proteins (PBPs) in carbapenem resistant Acinetobacter baumannii.
Article in The Indian journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
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- Carbapenem-resistant Gram-negative bacteria (CR-GNB) in ICUs: resistance genes, therapeutics, and prevention - a comprehensive review.Frontiers in public health · 2024Review
- Early detection of a possible multidrug-resistantIranian journal of microbiology · 2023Article
- Bacteriophages as therapeutic & disinfectant agents to tackle multidrug-resistantThe Indian journal of medical research · 2023Article
- Global Epidemiology and Mechanisms of Resistance of Acinetobacter baumannii-calcoaceticus Complex.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Insight into carbapenem resistance and virulence of Acinetobacter baumannii from a children's medical centre in eastern China.Annals of clinical microbiology and antimicrobials · 2022Article
- Evasion of Antimicrobial Activity inInternational journal of molecular sciences · 2022Review
- Molecular Characterization of Carbapenem-ResistantInfection and drug resistance · 2022Review
- Convergence of Biofilm Formation and Antibiotic Resistance inFrontiers in medicine · 2022Review
- Growth kinetics of multipleF1000Research · 2022Article
- Laboratory evolution of Mycobacterium on agar plates for analysis of resistance acquisition and drug sensitivity profiles.Scientific reports · 2021Article
- Interaction ofAntibiotics (Basel, Switzerland) · 2021Article
- Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesAcinetobacter baumannii is a Gram-negative, cocco-bacillus aerobic pathogen responsible for nosocomial infections in hospitals. In the recent past A. baumannii had developed resistance against β-lactams, even against carbapenems. Penicillin-binding proteins (PBPs) are crucial for the cell wall biosynthesis during cell proliferation and these are the target for β-lactams. Therefore, the present study was carried out to identify the PBPs in three (low, intermediate and high MICs) groups of carbapenem resistant isolates strains of A. baumannii.
methodsATCC 19606 and 20 β-lactam resistant isolates of A. baumannii were obtained. Selective identification of the PBPs was done using Bocillin FL, a non-radioactive fluorescent derivative of penicillin.
resultsThe fluorescence emission from Bocillin-tag in SDS-PAGE gel of native strain identified eight PBPs, with apparent molecular weight of 94, 65, 49, 40, 30, 24, 22 and 17 kDa, however, these PBPs revealed alteration in carbapenem-resistant isolates. INTERPRETATION &
conclusionsA comparative analysis of PBPs in the resistant isolates with those of ATCC revealed a decreased expression of all PBPs except that of 65 and 17 kDa PBPs which were marginally downregulated, and simultaneous appearance of new 28 kDa PBP (in low and intermediate resistant isolates) and 36 kDa in high meropenem resistant group of A. baumannii. The present study indicated an association between alteration in PBPs and β-lactam resistance in A. baumannii.
Indexed as
Identifiers
21441690PMC3103161W2120992606What OpenQuestion holds
Registered trials
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