ReviewAdvances in dental research2011
Epithelial cell innate response to Candida albicans.
Review in Advances in dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Functional analysis ofmBio · 2026Article
- Elevated vaginal heparan sulfate correlates with impaired neutrophil killing ofInfection and immunity · 2026Article
- Review
- Microbial adaptive pathogenicity strategies to the host inflammatory environment.FEMS microbiology reviews · 2025Review
- Protective Properties of S-layer Protein 2 fromBiomolecules · 2023Article
- Lipid Transport byInfection and immunity · 2022Article
- Cytokine-Mediated Inflammation in the Oral Cavity and Its Effect on Lipid Nanocarriers.Nanomaterials (Basel, Switzerland) · 2021Article
- Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells.Nature microbiology · 2021Article
- The Interactions BetweenFrontiers in microbiology · 2021Review
- Article
- Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway.PLoS genetics · 2019Article
- Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis.BMC microbiology · 2018Article
- Oral microbiota reduce wound healing capacity of epithelial monolayers, irrespective of the presence of 5-fluorouracil.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Altered Toll-like receptor expression and function in HPV-associated oropharyngeal carcinoma.Oncotarget · 2018Article
- Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.PLoS genetics · 2016Article
- Innate immune cell response upon Candida albicans infection.Virulence · 2016Review
- Article
- Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.Journal of microbiology (Seoul, Korea) · 2016Review
- Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis.Pathogens (Basel, Switzerland) · 2015Article
- Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses.Infection and immunity · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
With the advent of treatments and diseases such as AIDS resulting in increasing numbers of patients with suppressed immune systems, fungal diseases are an escalating problem. Candida albicans is the most common of these fungal pathogens, causing infections in many of these patients. It is therefore important to understand how immunity to this fungus is regulated and how it might be manipulated. Although work has been done to identify the receptors, fungal moieties, and responses involved in anti-Candida immunity, most studies have investigated interactions with myeloid or lymphoid cells. Given that the first site of contact of C. albicans with its host is the mucosal epithelial surface, recent studies have begun to focus on interactions of C. albicans with this site. The results are startling yet in retrospect obvious, indicating that epithelial cells play an important role in these interactions, initiating responses and even providing a level of protection. These findings have obvious implications, not just for fungal pathogens, but also for identifying how host organisms can distinguish between commensal and pathogenic microbes. This review highlights some of these recent findings and discusses their importance in the wider context of infection and immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.