ArticleThe Plant cell2011
The membrane mucin Msb2 regulates invasive growth and plant infection in Fusarium oxysporum.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 111 citations in OpenAlex.
- Phase-contrast microtomography unveils mechanisms of root colonization by a vascular fungal pathogen.Nature communications · 2026Article
- MaMsb2, a signaling mucin, is involved in conidiation, stress tolerances, and virulence in the entomopathogenic fungusVirulence · 2025Article
- Cell wall remodeling in a fungal pathogen is required for hyphal growth into microspaces.mBio · 2025Article
- Genetic and molecular approaches for Fusarium wilt resistance in garden pea: advances and future outlook.Plant molecular biology · 2025Review
- The SsSmk1-SsSom1-SsMsb2 Pathway Regulates Infection Cushion Formation and Pathogenicity in Sclerotinia sclerotiorum.Molecular plant pathology · 2025Article
- MSB2-activated pheromone pathway regulates fungal plasma membrane integrity in response to herbicide adjuvant.Science advances · 2025Article
- Role ofJournal of fungi (Basel, Switzerland) · 2024Article
- The Ubiquitous Wilt-Inducing PathogenPathogens (Basel, Switzerland) · 2024Review
- Rho2 involved in development, stress response and pathogenicity of Fusarium oxysporum.World journal of microbiology & biotechnology · 2023Article
- Article
- Constitutive activation of TORC1 signalling attenuates virulence in the cross-kingdom fungal pathogen Fusarium oxysporum.Molecular plant pathology · 2023Article
- Live-Cell Visualization of Early Stages of Root Colonization by the Vascular Wilt Pathogen Fusarium oxysporum.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The Gal4-Type Transcription Factor Pro1 Integrates Inputs from Two Different MAPK Cascades to Regulate Development in the Fungal PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Cell Wall Integrity and Its Industrial Applications in Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- SsAGM1-Mediated Uridine Diphosphate-Frontiers in microbiology · 2022Article
- Mucin Msb2 cooperates with the transmembrane protein Sho1 in various plant surface signal sensing and pathogenic processes in the poplar anthracnose fungus Colletotrichum gloeosporioides.Molecular plant pathology · 2021Article
- CgEnd3 Regulates Endocytosis, Appressorium Formation, and Virulence in the Poplar Anthracnose FungusInternational journal of molecular sciences · 2021Article
- The membrane mucin Msb2 regulates aflatoxin biosynthesis and pathogenicity in fungus Aspergillus flavus.Microbial biotechnology · 2021Article
- Developmental Roles of the Hog1 Protein Phosphatases of the Maize PathogenJournal of fungi (Basel, Switzerland) · 2021Article
- Proteome-Wide Analysis of Lysine 2-Hydroxyisobutyrylated Proteins inFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal pathogenicity in plants requires a conserved mitogen-activated protein kinase (MAPK) cascade homologous to the yeast filamentous growth pathway. How this signaling cascade is activated during infection remains poorly understood. In the soil-borne vascular wilt fungus Fusarium oxysporum, the orthologous MAPK Fmk1 (Fusarium MAPK1) is essential for root penetration and pathogenicity in tomato (Solanum lycopersicum) plants. Here, we show that Msb2, a highly glycosylated transmembrane protein, is required for surface-induced phosphorylation of Fmk1 and contributes to a subset of Fmk1-regulated functions related to invasive growth and virulence. Mutants lacking Msb2 share characteristic phenotypes with the Δfmk1 mutant, including defects in cellophane invasion, penetration of the root surface, and induction of vascular wilt symptoms in tomato plants. In contrast with Δfmk1, Δmsb2 mutants were hypersensitive to cell wall targeting compounds, a phenotype that was exacerbated in a Δmsb2 Δfmk1 double mutant. These results suggest that the membrane mucin Msb2 promotes invasive growth and plant infection upstream of Fmk1 while contributing to cell integrity through a distinct pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.