ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2011
Mineral abnormalities and long-term graft function in pediatric renal transplant recipients: a role for FGF-23?
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 46 citations in OpenAlex.
- Diagnosis and management of mineral and bone disorders in paediatric kidney transplant recipients: a position statement from the European Society for Paediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2026Review
- Post-transplant metabolic dysregulation: Insights and implications for kidney graft survival.World journal of nephrology · 2026Review
- Persistent hyperparathyroidism after kidney transplantation in children.Renal failure · 2025Article
- Significance of changes in FGF23 levels in childhood primary nephrotic syndrome and children who progress to end‑stage renal disease.Experimental and therapeutic medicine · 2023Article
- Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23.International journal of molecular sciences · 2023Review
- Body mass index is associated with hyperparathyroidism in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2021Article
- Short stature in advanced pediatric CKD is associated with faster time to reduced kidney function after transplant.Pediatric nephrology (Berlin, Germany) · 2019Article
- Mineral and Bone Disease in Kidney Transplant Recipients.Current osteoporosis reports · 2018Review
- Does Vitamin D Affect Chronic Renal Allograft Function in Pediatric Transplant Patients?Annals of transplantation · 2018Article
- The FGF23-Klotho axis and cardiac tissue Doppler imaging in pediatric chronic kidney disease-a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2018Observational
- Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study.Pediatric transplantation · 2016Article
- Phosphate and FGF-23 homeostasis after kidney transplantation.Nature reviews. Nephrology · 2015Review
- Mineral metabolism in European children living with a renal transplant: a European society for paediatric nephrology/european renal association-European dialysis and transplant association registry study.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Modernization of Chronic Allograft Injury Research: Better Biomarkers, Better Studies, Better Outcomes.Clinical transplants · 2015Article
- Vitamin D in renal transplantation - from biological mechanisms to clinical benefits.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Review
- FGF23 and mineral metabolism in the early post-renal transplantation period.Pediatric nephrology (Berlin, Germany) · 2013Article
- Plasma FGF23 levels increase rapidly after acute kidney injury.Kidney international · 2013Article
- Fibroblast growth factor-23 and calcium phosphate product in young chronic kidney disease patients: a cross-sectional study.BMC nephrology · 2013Article
- Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Association of pretransplant serum phosphorus with posttransplant outcomes.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
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5 authors at 4 institutions in 2 countries.
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Abstract
backgroundAlthough current guidelines recommend the evaluation of mineral and bone metabolism in patients with all stages of chronic kidney disease (CKD), the prevalence of altered mineral ion homeostasis in the pediatric posttransplant population is unknown. Moreover, the contribution of abnormal mineral ion metabolism to graft outcomes in this population has not been evaluated.
methodsSerum calcium, phosphorus, 25(OH)vitamin D, 1,25(OH)(2)vitamin D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) levels were evaluated 4.9 ± 0.5 years after transplantation in 68 stable pediatric renal allograft recipients. Patients were subsequently followed for 2 years.
resultsAt baseline, mean estimated glomerular filtration rate (GFR) was 60 ± 2 mL/min/1.73 m(2). Serum calcium and phosphorus values were within the reference interval. PTH values were elevated but did not differ by CKD stage. 25(OH)vitamin D levels were low in nearly half of all subjects. Tubular reabsorption of phosphate and 1,25(OH)(2)vitamin D values were lower, while FGF-23 and PTH values were higher in more advanced stages of CKD. Thirty percent of patients with FGF-23 values >110 RU/mL had a decrease in GFR of >50% (P < 0.05) and FGF-23 values predicted future episodes of rejection.
conclusionsDespite normal serum calcium and phosphorus levels in the majority of prevalent pediatric renal transplant recipients, abnormalities in PTH, 25(OH)vitamin D and FGF-23 are common. FGF-23 levels may be associated with increased risk for deterioration of kidney function and episodes of rejection.
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