ArticleAmerican journal of respiratory cell and molecular biology2011
Activation of beta1 integrins on blood eosinophils by P-selectin.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin.American journal of respiratory cell and molecular biology · 2013Trial
- Regulation of eosinophil recruitment and heterogeneity during allergic airway inflammation.Frontiers in allergy · 2025Review
- αJournal of personalized medicine · 2021Article
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- αThe Journal of allergy and clinical immunology · 2020Article
- Platelet-Adherent Leukocytes Associated With Cutaneous Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs.Frontiers in pharmacology · 2020Article
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- Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation.Haematologica · 2018Article
- Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge.International archives of allergy and immunology · 2018Article
- IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Eosinophil Activation Status in Separate Compartments and Association with Asthma.Frontiers in medicine · 2017Review
- Platelet-Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma.Frontiers in medicine · 2017Review
- Proteomics of Eosinophil Activation.Frontiers in medicine · 2017Review
- Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.Physiological reviews · 2016Review
- The Peripheral Blood Eosinophil Proteome.Journal of proteome research · 2016Article
- Activation states of blood eosinophils in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Review
- IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming.American journal of respiratory cell and molecular biology · 2014Article
- VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.The Journal of experimental medicine · 2013Article
- Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activation of β(1) integrins of blood eosinophils, assessed by mAb N29, correlates inversely with FEV(1) in two paradigms for studying control of human asthma. We asked whether P-selectin causes eosinophil β(1) integrin activation and results in increased adhesivity. By dual-label flow cytometry, eosinophils with high levels of surface-associated P-selectin had higher reactivity with the activation-sensitive anti-β(1) mAbs N29, 8E3, and 9EG7 than eosinophils with no or with a low-level of surface-associated P-selectin. Among patients with nonsevere asthma, surface P-selectin correlated with N29, 8E3, and 9EG7 signals. By immunofluorescence microscopy, surface-associated P-selectin was present in patches on eosinophils, some of which stained for the platelet marker thrombospondin-1. Activated β(1) and P-selectin partially colocalized on eosinophils. Soluble P-selectin added to whole blood enhanced activation of eosinophil β(1), but not β(2), integrins. In contrast, IL-5 activated eosinophil β(2), but not β(1), integrins. Eosinophils that did not attach to vascular cell adhesion molecule-1 (VCAM-1) in a static adhesion assay had a lower N29 signal than the original population. Soluble P-selectin added to whole blood enhanced eosinophil adhesion to VCAM-1. These findings are compatible with a scenario whereby P-selectin, on eosinophil-associated activated platelets or acquired from plasma or from prior interactions with endothelial cells or platelets, activates eosinophil α(4)β(1) integrin and stimulates eosinophils to adhere to VCAM-1 and move to the airway in asthma.
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Registered trials
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