ArticleApplied and environmental microbiology2011
Strain-dependent norovirus bioaccumulation in oysters.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
54 citing papers in PubMed, 128 citations in OpenAlex.
- Norovirus inter-species transmission in an ex vivo model is dependent on virus internalization capacity.Emerging microbes & infections · 2026Article
- Occurrence of Human Enteric Viruses in Retail Mussels Marketed in Burgos, Spain.Microorganisms · 2026Article
- Performance evaluation of methods for detecting enteric viruses in meat products.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Multi-Ligand Interactions Shape Human Norovirus Persistence, Transmission, and Control in Food Matrices.Viruses · 2026Review
- Shellfish as a Potential Source of Hepatitis E Virus: Epidemiological Evidence, Biological Plausibility, and Research Gaps.Viruses · 2026Review
- Review
- Research Progress on Biological Accumulation, Detection and Inactivation Technologies of Norovirus in Oysters.Foods (Basel, Switzerland) · 2023Review
- Species-SpecificMarine drugs · 2023Article
- A Deterministic Model for Understanding Nonlinear Viral Dynamics in Oysters.Applied and environmental microbiology · 2022Article
- Surveillance of Adenovirus and Norovirus Contaminants in the Water and Shellfish of Major Oyster Breeding Farms and Fishing Ports in Taiwan.Pathogens (Basel, Switzerland) · 2022Article
- Risk Assessment of Norovirus Illness from Consumption of Raw Oysters in the United States and in Canada.Risk analysis : an official publication of the Society for Risk Analysis · 2022Article
- Can shellfish be used to monitor SARS-CoV-2 in the coastal environment?The Science of the total environment · 2021Article
- Evaluation of Norovirus Reduction in Environmentally Contaminated Pacific Oysters During Laboratory Controlled and Commercial Depuration.Food and environmental virology · 2021Article
- Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species.Journal of virology · 2021Article
- Virucidal Effects of Dielectric Barrier Discharge Plasma on Human Norovirus Infectivity in Fresh Oysters (Foods (Basel, Switzerland) · 2020Article
- F-Specific RNA Bacteriophages Model the Behavior of Human Noroviruses during Purification of Oysters: the Main Mechanism Is Probably Inactivation Rather than Release.Applied and environmental microbiology · 2020Article
- Effect of natural ageing and heat treatments on GII.4 norovirus binding to Histo-Blood Group Antigens.Scientific reports · 2019Article
- Norovirus Detection at Oualidia Lagoon, a Moroccan Shellfish Harvesting Area, by Reverse Transcription PCR Analysis.Food and environmental virology · 2019Article
- Detection of Human Enteric Viruses in French Polynesian Wastewaters, Environmental Waters and Giant Clams.Food and environmental virology · 2019Article
- Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Noroviruses (NoVs) are the main agents of gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Some NoV strains bind to shellfish tissues by using carbohydrate structures similar to their human ligands, leading to the hypothesis that such ligands may influence bioaccumulation. This study compares the bioaccumulation efficiencies and tissue distributions in oysters (Crassostrea gigas) of three strains from the two principal human norovirus genogroups. Clear differences between strains were observed. The GI.1 strain was the most efficiently concentrated strain. Bioaccumulation specifically occurred in digestive tissues in a dose-dependent manner, and its efficiency paralleled ligand expression, which was highest during the cold months. In comparison, the GII.4 strain was very poorly bioaccumulated and was recovered in almost all tissues without seasonal influence. The GII.3 strain presented an intermediate behavior, without seasonal effect and with less bioaccumulation efficiency than that of the GI.1 strain during the cold months. In addition, the GII.3 strain was transiently concentrated in gills and mantle before being almost specifically accumulated in digestive tissues. Carbohydrate ligand specificities of the strains at least partly explain the strain-dependent bioaccumulation characteristics. In particular, binding to the digestive-tube-specific ligand should contribute to bioaccumulation, whereas we hypothesize that binding to the sialic acid-containing ligand present in all tissues would contribute to retain virus particles in the gills or mantle and lead to rapid destruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.