ArticleMolecular biology of the cell2011
The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Replication program of a single-chromosome budding yeast strain.Nucleic acids research · 2025Article
- Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming.Nature communications · 2025Article
- Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.Nucleus (Austin, Tex.) · 2023Review
- Ribosomal DNA replication time coordinates completion of genome replication and anaphase in yeast.Cell reports · 2023Article
- Rif1-Dependent Control of Replication Timing.Genes · 2022Review
- The capacity of origins to load MCM establishes replication timing patterns.PLoS genetics · 2021Article
- ChECing out Rif1 action in freely cycling cells.Current genetics · 2019Review
- Review
- The Protective Role of Dormant Origins in Response to Replicative Stress.International journal of molecular sciences · 2018Review
- Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.EMBO reports · 2018Article
- Rif1 phosphorylation site analysis in telomere length regulation and the response to damaged telomeres.DNA repair · 2018Article
- An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres.PLoS genetics · 2018Article
- Investigating the role of Rts1 in DNA replication initiation.Wellcome open research · 2018Article
- Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.EMBO reports · 2017Article
- Model-based analysis of DNA replication profiles: predicting replication fork velocity and initiation rate by profiling free-cycling cells.Genome research · 2017Article
- Solving the Telomere Replication Problem.Genes · 2017Review
- Review
- How and why multiple MCMs are loaded at origins of DNA replication.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Regulating telomere length from the inside out: the replication fork model.Genes & development · 2016Article
- Rif1 Regulates the Fate of DNA Entanglements during Mitosis.Cell reports · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
DNA replication in Saccharomyces cerevisiae proceeds according to a temporal program. We have investigated the role of the telomere-binding Ku complex in specifying late replication of telomere-proximal sequences. Genome-wide analysis shows that regions extending up to 80 kb from telomeres replicate abnormally early in a yku70 mutant. We find that Ku does not appear to regulate replication time by binding replication origins directly, nor is its effect on telomere replication timing mediated by histone tail acetylation. We show that Ku instead regulates replication timing through its effect on telomere length, because deletion of the telomerase regulator Pif1 largely reverses the short telomere defect of a yku70 mutant and simultaneously rescues its replication timing defect. Consistent with this conclusion, deleting the genome integrity component Elg1 partially rescued both length and replication timing of yku70 telomeres. Telomere length-mediated control of replication timing requires the TG(1-3) repeat-counting component Rif1, because a rif1 mutant replicates telomeric regions early, despite having extended TG(1-3) tracts. Overall, our results suggest that the effect of Ku on telomere replication timing results from its impact on TG(1-3) repeat length and support a model in which Rif1 measures telomere repeat length to ensure that telomere replication timing is correctly programmed.
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